Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1

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	Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1
	Fang, H; Ren, WL; Cui, QX; Liang, HC; Yang, CY; Liu, WJ; Wang, XY; Liu, X; Shi, YJ; Feng, J; Chen, CS
	2023
发表期刊	ELIFE
ISSN	2050-084X
卷号	12
摘要	Anti-tumor drug resistance is a challenge for human triple-negative breast cancer (TNBC) treatment. Our previous work demonstrated that TNFAIP2 activates RAC1 to promote TNBC cell proliferation and migration. However, the mechanism by which TNFAIP2 activates RAC1 is unknown. In this study, we found that TNFAIP2 interacts with IQGAP1 and Integrin beta 4. Integrin beta 4 activates RAC1 through TNFAIP2 and IQGAP1 and confers DNA damage-related drug resistance in TNBC. These results indicate that the Integrin beta 4/TNFAIP2/IQGAP1/RAC1 axis provides potential therapeutic targets to overcome DNA damage-related drug resistance in TNBC.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14185
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Fang, H,Ren, WL,Cui, QX,et al. Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1[J]. ELIFE,2023,12.
APA	Fang, H.,Ren, WL.,Cui, QX.,Liang, HC.,Yang, CY.,...&Chen, CS.(2023).Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1.ELIFE,12.
MLA	Fang, H,et al."Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1".ELIFE 12(2023).

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