Targeting Breast Cancer Stem Cells

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Targeting Breast Cancer Stem Cells
	Zhang, L; Chen, WM; Liu, SL; Chen, CS
	2023
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN	1449-2288
卷号	19 期号:2 页码:552-570
摘要	The potential roles of breast cancer stem cells (BCSCs) in tumor initiation and recurrence have been recognized for many decades. Due to their strong capacity for self-renewal and differentiation, BCSCs are the major reasons for poor clinical outcomes and low therapeutic response. Several hypotheses on the origin of cancer stem cells have been proposed, including critical gene mutations in stem cells, dedifferentiation of somatic cells, and cell plasticity remodeling by epithelial-mesenchymal transition (EMT) and the tumor microenvironment. Moreover, the tumor microenvironment, including cellular components and cytokines, modulates the self-renewal and therapeutic resistance of BCSCs. Small molecules, antibodies, and chimeric antigen receptor (CAR)-T cells targeting BCSCs have been developed, and their applications in combination with conventional therapies are undergoing clinical trials. In this review, we focus on the features of BCSCs, emphasize the major factors and tumor environment that regulate the stemness of BCSCs, and discuss potential BCSC-targeting therapies.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14191
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Zhang, L,Chen, WM,Liu, SL,et al. Targeting Breast Cancer Stem Cells[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2023,19(2):552-570.
APA	Zhang, L,Chen, WM,Liu, SL,&Chen, CS.(2023).Targeting Breast Cancer Stem Cells.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,19(2),552-570.
MLA	Zhang, L,et al."Targeting Breast Cancer Stem Cells".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 19.2(2023):552-570.

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