Phorbol Derivatives of Croton Oil

	Phorbol Derivatives of Croton Oil
	Huang, XL; Huang, XS; Li, QR; Yang, LM; Cui, YD; Zheng, YT; Zhang, J
	2024
发表期刊	CHEMISTRY OF NATURAL COMPOUNDS
ISSN	0009-3130
卷号	60 期号:2 页码:247-251
摘要	One new seco-cyclic phorbol derivative and one new phorbol 12-monoester, named 13-oxo-14-isopropylphorbol (2), 12-angelylphorbol (5), together with four known compounds, named 4a-deoxyphorbol, 13-oxo-14-isopropenylphorbol, 12-isobutyrylphorbol, and phorbol-12-(2-methylbutyrate) were obtained by hydrolyzing croton oil. The structures of the compounds were elucidated by spectroscopic analysis. These compounds showed no cytotoxicity (CC50 > 200 mu M). Phorbol-12-monoesters 4-6 showed the weak inhibitory activities on syncytia formation induced by HIV-1IIIB (4, EC50 = 56.05 mu M; 5, EC50 = 72.97 mu M; 6, EC50 = 52.58 mu M). The seco-cyclic phorbol derivatives (2, 3) showed no anti-HIV-1 activities (EC50 > 200 mu M), which indicated that chemical cleavage of cyclopropanols might affect anti-HIV-1 activity.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14204
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Huang, XL,Huang, XS,Li, QR,et al. Phorbol Derivatives of Croton Oil[J]. CHEMISTRY OF NATURAL COMPOUNDS,2024,60(2):247-251.
APA	Huang, XL.,Huang, XS.,Li, QR.,Yang, LM.,Cui, YD.,...&Zhang, J.(2024).Phorbol Derivatives of Croton Oil.CHEMISTRY OF NATURAL COMPOUNDS,60(2),247-251.
MLA	Huang, XL,et al."Phorbol Derivatives of Croton Oil".CHEMISTRY OF NATURAL COMPOUNDS 60.2(2024):247-251.

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