Identification of novel mammalian viruses in tree shrews (Tupaia belangeri chinensis)

	Identification of novel mammalian viruses in tree shrews (Tupaia belangeri chinensis)
	Zhou, H; Tian, RR; Wang, XR; Yang, JX; Wang, YX; Zhao, ML; Zhang, XD; Ma, YH; Lv, LB; Holmes, EC; Zheng, YT; Shi, WF
	2024
发表期刊	ZOOLOGICAL RESEARCH
ISSN	2095-8137
卷号	45 期号:2 页码:429-438
摘要	The Chinese tree shrew (Tupaia belangeri chinensis), a member of the mammalian order Scandentia, exhibits considerable similarities with primates, including humans, in aspects of its nervous, immune, and metabolic systems. These similarities have established the tree shrew as a promising experimental model for biomedical research on cancer, infectious diseases, metabolic disorders, and mental health conditions. Herein, we used metatranscriptomic sequencing to analyze plasma, as well as oral and anal swab samples, from 105 healthy asymptomatic tree shrews to identify the presence of potential zoonotic viruses. In total, eight mammalian viruses with complete genomes were identified, belonging to six viral families, including Flaviviridae, Hepeviridae, Parvovirinae, Picornaviridae, Sedoreoviridae, and Spinareoviridae. Notably, the presence of rotavirus was recorded in tree shrews for the first time. Three viruses - hepacivirus 1, parvovirus, and picornavirus - exhibited low genetic similarity (<70%) with previously reported viruses at the whole-genome scale, indicating novelty. Conversely, three other viruses - hepacivirus 2, hepatovirus A and hepevirus - exhibited high similarity (>94%) to known viral strains. Phylogenetic analyses also revealed that the rotavirus and mammalian orthoreovirus identified in this study may be novel reassortants. These findings provide insights into the diverse viral spectrum present in captive Chinese tree shrews, highlighting the necessity for further research into their potential for crossspecies transmission.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14210
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Zhou, H,Tian, RR,Wang, XR,et al. Identification of novel mammalian viruses in tree shrews (Tupaia belangeri chinensis)[J]. ZOOLOGICAL RESEARCH,2024,45(2):429-438.
APA	Zhou, H.,Tian, RR.,Wang, XR.,Yang, JX.,Wang, YX.,...&Shi, WF.(2024).Identification of novel mammalian viruses in tree shrews (Tupaia belangeri chinensis).ZOOLOGICAL RESEARCH,45(2),429-438.
MLA	Zhou, H,et al."Identification of novel mammalian viruses in tree shrews (Tupaia belangeri chinensis)".ZOOLOGICAL RESEARCH 45.2(2024):429-438.

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