Nanoparticles insert a three dimensional cavity structure of proteins for function inhibition: The Case of CeO2 and SARS-CoV-2

	Nanoparticles insert a three dimensional cavity structure of proteins for function inhibition: The Case of CeO2 and SARS-CoV-2
	Zhang, GF; Wang, XF; Wang, GC; Suo, XM; Qiu, Y; Luo, RH; Liu, YN; Li, Q; Luo, WH; Shi, ZZ; Liu, FF; Li, ZD; Qu, J; Li, L; Bastus, NG; Himly, M; Wang, LM; Liu, FL; Zheng, YT; Puntes, V; Li, Y
	2024
发表期刊	NANO TODAY
ISSN	1748-0132
卷号	55
摘要	The selective interaction of nanomaterials with proteins for protein function suppression has been reported. However, whether the nanomaterials could be used to target a three-dimensional (3D) structure of proteins for the consequent function inhibition is not defined. When SARS-CoV-2 binds to the host cell surface ACE2 receptor, the spike protein trimer changes to an "Open State" which forms a 5 nm cavity structure, consequently exposing the receptor binding domain (RBD) for the following viral infection. We found that the 3 nm cerium oxide nanoparticles (CeO2@3) showed a better anti-SARS-CoV-2 effect than 30 nm cerium oxide nanoparticles (CeO2@30). We performed a series of experiments and demonstrated that the CeO2@3 could target the 5 nm spike protein trimer cavity and tightly bind with the RBD, thus effectively blocking the following virus-cell interaction and rendering CeO2@3 as an effective anti-viral agent. As all coronaviruses possess similar spike protein structures as homologous proteins, CeO2@3 can be used as a broad-sperm anti-coronavirus nanodrug candidate by targeting the spike protein 3D structure. This work, for the first time, demonstrated that rationally engineered inorganic nanomaterials can be used to specifically target a 3D structure of a certain protein for function inhibition, thus providing a novel methodological approach and paving the way for future molecular targeting nanodrug candidate design.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14213
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Zhang, GF,Wang, XF,Wang, GC,et al. Nanoparticles insert a three dimensional cavity structure of proteins for function inhibition: The Case of CeO2 and SARS-CoV-2[J]. NANO TODAY,2024,55.
APA	Zhang, GF.,Wang, XF.,Wang, GC.,Suo, XM.,Qiu, Y.,...&Li, Y.(2024).Nanoparticles insert a three dimensional cavity structure of proteins for function inhibition: The Case of CeO2 and SARS-CoV-2.NANO TODAY,55.
MLA	Zhang, GF,et al."Nanoparticles insert a three dimensional cavity structure of proteins for function inhibition: The Case of CeO2 and SARS-CoV-2".NANO TODAY 55(2024).

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