| Blap-6, a Novel Antifungal Peptide from the Chinese Medicinal Beetle Blaps rhynchopetera against Cryptococcus neoformans | |
| Zhang, LM; Zhou, SW; Huang, XS; Chen, YF; Mwangi, J; Fang, YQ; Du, T; Zhao, M; Shi, L; Lu, QM | |
| 2024 | |
| 发表期刊 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| ISSN | 1661-6596 |
| 卷号 | 25期号:10 |
| 摘要 | Cryptococcus neoformans (C. neoformans) is a pathogenic fungus that can cause life-threatening meningitis, particularly in individuals with compromised immune systems. The current standard treatment involves the combination of amphotericin B and azole drugs, but this regimen often leads to inevitable toxicity in patients. Therefore, there is an urgent need to develop new antifungal drugs with improved safety profiles. We screened antimicrobial peptides from the hemolymph transcriptome of Blaps rhynchopetera (B. rhynchopetera), a folk Chinese medicine. We found an antimicrobial peptide named blap-6 that exhibited potent activity against bacteria and fungi. Blap-6 is composed of 17 amino acids (KRCRFRIYRWGFPRRRF), and it has excellent antifungal activity against C. neoformans, with a minimum inhibitory concentration (MIC) of 0.81 mu M. Blap-6 exhibits strong antifungal kinetic characteristics. Mechanistic studies revealed that blap-6 exerts its antifungal activity by penetrating and disrupting the integrity of the fungal cell membrane. In addition to its direct antifungal effect, blap-6 showed strong biofilm inhibition and scavenging activity. Notably, the peptide exhibited low hemolytic and cytotoxicity to human cells and may be a potential candidate antimicrobial drug for fungal infection caused by C. neoformans. |
| 收录类别 | sci |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14219 |
| 专题 | 科研部门_天然药物功能蛋白质学科组（赖仞） |
| 推荐引用方式 GB/T 7714 | Zhang, LM,Zhou, SW,Huang, XS,et al. Blap-6, a Novel Antifungal Peptide from the Chinese Medicinal Beetle Blaps rhynchopetera against Cryptococcus neoformans[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2024,25(10). |
| APA | Zhang, LM.,Zhou, SW.,Huang, XS.,Chen, YF.,Mwangi, J.,...&Lu, QM.(2024).Blap-6, a Novel Antifungal Peptide from the Chinese Medicinal Beetle Blaps rhynchopetera against Cryptococcus neoformans.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,25(10). |
| MLA | Zhang, LM,et al."Blap-6, a Novel Antifungal Peptide from the Chinese Medicinal Beetle Blaps rhynchopetera against Cryptococcus neoformans".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25.10(2024). |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2024073117.pdf（3127KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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