Metabolic Heterogeneity and Potential Immunotherapeutic Responses Revealed by Single-Cell Transcriptomics of Breast Cancer

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Metabolic Heterogeneity and Potential Immunotherapeutic Responses Revealed by Single-Cell Transcriptomics of Breast Cancer
	Tang, SC; Wang, Q; Sun, K; Song, Y; Liu, R; Tan, X; Li, HM; Lv, YF; Yang, FY; Zhao, JW; Li, SJ; Bi, PP; Yang, JL; Zhu, ZN; Chen, D; Chuan, Z; Luo, XM; Hu, ZX; Liu, Y; Li, ZH; Ke, TF; Jiang, DW; Zheng, K; Yang, RR; Chen, K; Guo, R
	2024
发表期刊	APOPTOSIS
ISSN	1360-8185
摘要	BackgroundBreast cancer (BC) exhibits remarkable heterogeneity. However, the transcriptomic heterogeneity of BC at the single-cell level has not been fully elucidated.MethodsWe acquired BC samples from 14 patients. Single-cell RNA sequencing (scRNA-seq), bioinformatic analyses, along with immunohistochemistry (IHC) and immunofluorescence (IF) assays were carried out.ResultsAccording to the scRNA-seq results, 10 different cell types were identified. We found that Cancer-Associated Fibroblasts (CAFs) exhibited distinct biological functions and may promote resistance to therapy. Metabolic analysis of tumor cells revealed heterogeneity in glycolysis, gluconeogenesis, and fatty acid synthetase reprogramming, which led to chemotherapy resistance. Furthermore, patients with multiple metastases and progression were predicted to benefit from immunotherapy based on a heterogeneity analysis of T cells and tumor cells.ConclusionsOur findings provide a comprehensive understanding of the heterogeneity of BC, provide comprehensive insight into the correlation between cancer metabolism and chemotherapy resistance, and enable the prediction of immunotherapy responses based on T-cell heterogeneity.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14231
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Tang, SC,Wang, Q,Sun, K,et al. Metabolic Heterogeneity and Potential Immunotherapeutic Responses Revealed by Single-Cell Transcriptomics of Breast Cancer[J]. APOPTOSIS,2024.
APA	Tang, SC.,Wang, Q.,Sun, K.,Song, Y.,Liu, R.,...&Guo, R.(2024).Metabolic Heterogeneity and Potential Immunotherapeutic Responses Revealed by Single-Cell Transcriptomics of Breast Cancer.APOPTOSIS.
MLA	Tang, SC,et al."Metabolic Heterogeneity and Potential Immunotherapeutic Responses Revealed by Single-Cell Transcriptomics of Breast Cancer".APOPTOSIS (2024).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2024080124.pdf（6594KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文