A compendium of genetic regulatory effects across pig tissues

	A compendium of genetic regulatory effects across pig tissues
	Teng, JY; Gao, YH; Yin, HW; Bai, ZH; Liu, SL; Zeng, HN; Bai, LJ; Cai, ZX; Zhao, BR; Li, XJ; Xu, ZT; Lin, Q; Pan, ZY; Yang, WJ; Yu, XS; Guan, DL; Hou, YL; Keel, BN; Rohrer, GA; Lindholm-Perry, AK; Oliver, WT; Ballester, M; Crespo-Piazuelo, D; Quintanilla, R; Canela-Xandri, O; Rawlik, K; Xia, C; Yao, YL; Zhao, QY; Yao, WY; Yang, L; Li, HC; Zhang, HC; Liao, W; Chen, TS; Karlskov-Mortensen, P; Fredholm, M; Amills, M; Clop, A; Giuffra, E; Wu, J; Cai, XD; Diao, SQ; Pan, XC; Wei, C; Li, JH; Cheng, H; Wang, S; Su, GS; Sahana, G; Lund, MS; Dekkers, JCM; Kramer, L; Tuggle, CK; Corbett, R; Groenen, MAM; Madsen, O; Godia, M; Rocha, D; Charles, M; Li, CJ; Pausch, H; Hu, XX; Frantz, L; Luo, YH; Lin, L; Zhou, ZY; Zhang, Z; Chen, ZT; Cui, LL; Xiang, RD; Shen, X; Li, PH; Huang, RH; Tang, GQ; Li, MZ; Zhao, YX; Yi, GQ; Tang, ZL; Jiang, JC; Zhao, FP; Yuan, XL; Liu, XH; Chen, YS; Xu, XW; Zhao, SH; Zhao, PJ; Haley, C; Zhou, HJ; Wang, QS; Pan, YC; Ding, XD; Ma, L; Li, JQ; Navarro, P; Zhang, Q; Li, BJ; Tenesa, A; Li, K; Liu, GE; Zhang, Z; Fang, LZ
	2024
发表期刊	NATURE GENETICS
ISSN	1061-4036
卷号	56 期号:1
摘要	The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biological discovery and exploitation in animal breeding and human biomedicine. Here we show results from the pilot phase of PigGTEx by processing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples passing quality control from pigs. We build a pig genotype imputation panel and associate millions of genetic variants with five types of transcriptomic phenotypes in 34 tissues. We evaluate tissue specificity of regulatory effects and elucidate molecular mechanisms of their action using multi-omics data. Leveraging this resource, we decipher regulatory mechanisms underlying 207 pig complex phenotypes and demonstrate the similarity of pigs to humans in gene expression and the genetic regulation behind complex phenotypes, supporting the importance of pigs as a human biomedical model.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14239
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Teng, JY,Gao, YH,Yin, HW,et al. A compendium of genetic regulatory effects across pig tissues[J]. NATURE GENETICS,2024,56(1).
APA	Teng, JY.,Gao, YH.,Yin, HW.,Bai, ZH.,Liu, SL.,...&Fang, LZ.(2024).A compendium of genetic regulatory effects across pig tissues.NATURE GENETICS,56(1).
MLA	Teng, JY,et al."A compendium of genetic regulatory effects across pig tissues".NATURE GENETICS 56.1(2024).

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2024080132.pdf（19778KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文