Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds

	Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds
	Wang, SZ; Yan, Y; Widlund, M; Qian, CC; Zhang, LL; Zhang, SJ; Li, ZM; Cao, P; Dai, QY; Feng, XT; Liu, F; Wang, L; Gao, C; Fu, QM; Hytönen, MK; Lohi, H; Savolainen, P; Wang, GD
	2024
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	41 期号:7
摘要	The origins and extreme morphological evolution of the modern dog breeds are poorly studied because the founder populations are extinct. Here, we analyse eight 100 to 200 years old dog fur samples obtained from traditional North Swedish clothing, to explore the origin and artificial selection of the modern Nordic Lapphund and Elkhound dog breeds. Population genomic analysis confirmed the Lapphund and Elkhound breeds to originate from the local dog population, and showed a distinct decrease in genetic diversity in agreement with intense breeding. We identified eleven genes under positive selection during the breed development. In particular, the MSRB3 gene, associated with breed-related ear morphology, was selected in all Lapphund and Elkhound breeds, and functional assays showed that a SNP mutation in the 3 ' UTR region suppresses its expression through miRNA regulation. Our findings demonstrate analysis of near-modern dog artifacts as an effective tool for interpreting the origin and artificial selection of the modern dog breeds.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14247
专题	科研部门_行为遗传与进化（王国栋）
推荐引用方式 GB/T 7714	Wang, SZ,Yan, Y,Widlund, M,et al. Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds[J]. MOLECULAR BIOLOGY AND EVOLUTION,2024,41(7).
APA	Wang, SZ.,Yan, Y.,Widlund, M.,Qian, CC.,Zhang, LL.,...&Wang, GD.(2024).Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds.MOLECULAR BIOLOGY AND EVOLUTION,41(7).
MLA	Wang, SZ,et al."Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds".MOLECULAR BIOLOGY AND EVOLUTION 41.7(2024).

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2024073116.pdf（859KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文