Corydecusines A-H, new phthalideisoquinoline hemicetal alkaloids from the bulbs of Corydalis decumbens inhibit Tau pathology by activating autophagy mediated by AMPK-ULK1 pathway

	Corydecusines A-H, new phthalideisoquinoline hemicetal alkaloids from the bulbs of Corydalis decumbens inhibit Tau pathology by activating autophagy mediated by AMPK-ULK1 pathway
	Li, S; Luo, RC; Liang, ZZ; Zhang, BD; Wei, YL; Wen, HY; Dong, J; Li, XY; Guo, LL; Hao, XJ; Li, N; Zhang, Y
	2024
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	144
摘要	Twelve phthalideisoquinoline hemiacetal alkaloids including eight new ones (1-8) and one natural alkaloid characterized by an aziridine moiety with unassigned NMR data (9), were isolated and identified from the bulbs of Corydalis decumbens. Their structures were established by comprehensive analyses of HRESIMS, NMR, X-ray crystallography, and ECD analyses. The unambiguously established structures of the phthalideisoquinoline hemiacetal alkaloids indicated that the absolute configurations of C-1, C-9, and C-7 ' were confusable only relied on coupling constants. A summary of their ECD spectra was concluded and provided an insight for C-1, C-9, and C-7 ' absolute configuration assignment. These new compounds were evaluated to induce autophagy flux through flow cytometry analysis. Moreover, compounds 2 and 6 could significantly induce autophagy and inhibit Tau pathology by AMPK-ULK1 pathway activation, which provided an avenue for anti-AD lead compounds discovery.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14249
专题	科研部门_适应性进化与进化医学（吕雪梅）
推荐引用方式 GB/T 7714	Li, S,Luo, RC,Liang, ZZ,et al. Corydecusines A-H, new phthalideisoquinoline hemicetal alkaloids from the bulbs of Corydalis decumbens inhibit Tau pathology by activating autophagy mediated by AMPK-ULK1 pathway[J]. BIOORGANIC CHEMISTRY,2024,144.
APA	Li, S.,Luo, RC.,Liang, ZZ.,Zhang, BD.,Wei, YL.,...&Zhang, Y.(2024).Corydecusines A-H, new phthalideisoquinoline hemicetal alkaloids from the bulbs of Corydalis decumbens inhibit Tau pathology by activating autophagy mediated by AMPK-ULK1 pathway.BIOORGANIC CHEMISTRY,144.
MLA	Li, S,et al."Corydecusines A-H, new phthalideisoquinoline hemicetal alkaloids from the bulbs of Corydalis decumbens inhibit Tau pathology by activating autophagy mediated by AMPK-ULK1 pathway".BIOORGANIC CHEMISTRY 144(2024).

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