RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination

	RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination
	Li, YW; Wan, LP; Song, NN; Ding, YQ; Zhao, SH; Niu, JQ; Mao, BY; Sheng, NY; Ma, PC
	2024
发表期刊	SCIENCE ADVANCES
ISSN	2375-2548
卷号	10 期号:6
摘要	Maldevelopment of oligodendroglia underlies neural developmental disorders such as leukodystrophy. Precise regulation of the activity of specific transcription factors (TFs) by various posttranslational modifications (PTMs) is required to ensure proper oligodendroglial development and myelination. However, the role of ubiquitination of these TFs during oligodendroglial development is yet unexplored. Here, we find that RNF220, a known leukodystrophy-related E3 ubiquitin ligase, is required for oligodendroglial development. RNF220 depletion in oligodendrocyte lineage cells impedes oligodendrocyte progenitor cell proliferation, differentiation, and (re)myelination, which consequently leads to learning and memory defects. Mechanistically, RNF220 targets Olig1/2 for K63-linked polyubiquitination and stabilization during oligodendroglial development. Furthermore, in a knock-in mouse model of leukodystrophy-related RNF220(R365Q) mutation, the ubiquitination and stabilization of Olig proteins are deregulated in oligodendroglial cells. This results in pathomimetic oligodendroglial developmental defects, impaired myelination, and abnormal behaviors. Together, our evidence provides an alternative insight into PTMs of oligodendroglial TFs and how this essential process may be implicated in the etiology of leukodystrophy.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14250
专题	科研部门_神经突触机制与功能研究组（盛能印）
推荐引用方式 GB/T 7714	Li, YW,Wan, LP,Song, NN,et al. RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination[J]. SCIENCE ADVANCES,2024,10(6).
APA	Li, YW.,Wan, LP.,Song, NN.,Ding, YQ.,Zhao, SH.,...&Ma, PC.(2024).RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination.SCIENCE ADVANCES,10(6).
MLA	Li, YW,et al."RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination".SCIENCE ADVANCES 10.6(2024).

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