Fused in sarcoma (FUS) inhibits milk production efficiency in mammals

	Fused in sarcoma (FUS) inhibits milk production efficiency in mammals
	Shao, HL; Huang, JP; Wang, H; Wang, GL; Yang, X; Cheng, M; Sun, CJ; Zou, L; Yang, Q; Zhang, DD; Liu, Z; Jiang, XL; Shi, L; Shi, P; Han, BW; Jiao, BW
	2024
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	15 期号:1
摘要	Efficient milk production in mammals confers evolutionary advantages by facilitating the transmission of energy from mother to offspring. However, the regulatory mechanism responsible for the gradual establishment of milk production efficiency in mammals, from marsupials to eutherians, remains elusive. Here, we find that mammary gland of the marsupial sugar glider contained milk components during adolescence, and that mammary gland development is less dynamically cyclic compared to that in placental mammals. Furthermore, fused in sarcoma (FUS) is found to be partially responsible for this establishment of low efficiency. In mouse model, FUS inhibit mammary epithelial cell differentiation through the cyclin-dependent kinase inhibitor p57Kip2, leading to lactation failure and pup starvation. Clinically, FUS levels are negatively correlated with milk production in lactating women. Overall, our results shed light on FUS as a negative regulator of milk production, providing a potential mechanism for the establishment of milk production from marsupial to eutherian mammals. Efficient milk production in mammals confers advantages by facilitating the transmission of energy from mother to offspring. However, the factors for establishing the efficiency in mammals are unknown. Here, the authors identify FUS as a regulator of efficient milk production in mammals.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14259
专题	科研部门_发育的印迹调控与进化学（焦保卫）
推荐引用方式 GB/T 7714	Shao, HL,Huang, JP,Wang, H,et al. Fused in sarcoma (FUS) inhibits milk production efficiency in mammals[J]. NATURE COMMUNICATIONS,2024,15(1).
APA	Shao, HL.,Huang, JP.,Wang, H.,Wang, GL.,Yang, X.,...&Jiao, BW.(2024).Fused in sarcoma (FUS) inhibits milk production efficiency in mammals.NATURE COMMUNICATIONS,15(1).
MLA	Shao, HL,et al."Fused in sarcoma (FUS) inhibits milk production efficiency in mammals".NATURE COMMUNICATIONS 15.1(2024).

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