The role of TGF-β signaling in muscle atrophy, sarcopenia and cancer cachexia

	The role of TGF-β signaling in muscle atrophy, sarcopenia and cancer cachexia
	Lan, XQ; Deng, CJ; Wang, QQ; Zhao, LM; Jiao, BW; Xiang, Y
	2024
发表期刊	GENERAL AND COMPARATIVE ENDOCRINOLOGY
ISSN	0016-6480
卷号	353
摘要	Skeletal muscle, comprising a significant proportion (40 to 50 percent) of total body weight in humans, plays a critical role in maintaining normal physiological conditions. Muscle atrophy occurs when the rate of protein degradation exceeds protein synthesis. Sarcopenia refers to age-related muscle atrophy, while cachexia represents a more complex form of muscle wasting associated with various diseases such as cancer, heart failure, and AIDS. Recent research has highlighted the involvement of signaling pathways, including IGF1-Akt-mTOR, MuRF1-MAFbx, and FOXO, in regulating the delicate balance between muscle protein synthesis and breakdown. Myostatin, a member of the TGF-beta superfamily, negatively regulates muscle growth and promotes muscle atrophy by activating Smad2 and Smad3. It also interacts with other signaling pathways in cachexia and sarcopenia. Inhibition of myostatin has emerged as a promising therapeutic approach for sarcopenia and cachexia. Additionally, other TGF-beta family members, such as TGF-beta 1, activin A, and GDF11, have been implicated in the regulation of skeletal muscle mass. Furthermore, myostatin cooperates with these family members to impair muscle differentiation and contribute to muscle loss. This review provides an overview of the significance of myostatin and other TGF-beta signaling pathway members in muscular dystrophy, sarcopenia, and cachexia. It also discusses potential novel therapeutic strategies targeting myostatin and TGF-beta signaling for the treatment of muscle atrophy.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14260
专题	科研部门_发育的印迹调控与进化学（焦保卫）
推荐引用方式 GB/T 7714	Lan, XQ,Deng, CJ,Wang, QQ,et al. The role of TGF-β signaling in muscle atrophy, sarcopenia and cancer cachexia[J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY,2024,353.
APA	Lan, XQ,Deng, CJ,Wang, QQ,Zhao, LM,Jiao, BW,&Xiang, Y.(2024).The role of TGF-β signaling in muscle atrophy, sarcopenia and cancer cachexia.GENERAL AND COMPARATIVE ENDOCRINOLOGY,353.
MLA	Lan, XQ,et al."The role of TGF-β signaling in muscle atrophy, sarcopenia and cancer cachexia".GENERAL AND COMPARATIVE ENDOCRINOLOGY 353(2024).

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