| Methylation entropy landscape of Chinese long-lived individuals reveals lower epigenetic noise related to human healthy aging | |
| Wang, HT; Xiao, FH; Gao, ZL; Guo, LY; Yang, LQ; Li, GH; Kong, QP | |
| 2024 | |
| 发表期刊 | AGING CELL
 |
| ISSN | 1474-9718 |
| 卷号 | 23期号:7 |
| 摘要 | The transition from ordered to noisy is a significant epigenetic signature of aging and age-related disease. As a paradigm of healthy human aging and longevity, long-lived individuals (LLI, >90 years old) may possess characteristic strategies in coping with the disordered epigenetic regulation. In this study, we constructed high-resolution blood epigenetic noise landscapes for this cohort by a methylation entropy (ME) method using whole genome bisulfite sequencing (WGBS). Although a universal increase in global ME occurred with chronological age in general control samples, this trend was suppressed in LLIs. Importantly, we identified 38,923 genomic regions with LLI-specific lower ME (LLI-specific lower entropy regions, for short, LLI-specific LERs). These regions were overrepresented in promoters, which likely function in transcriptional noise suppression. Genes associated with LLI-specific LERs have a considerable impact on SNP-based heritability of some aging-related disorders (e.g., asthma and stroke). Furthermore, neutrophil was identified as the primary cell type sustaining LLI-specific LERs. Our results highlight the stability of epigenetic order in promoters of genes involved with aging and age-related disorders within LLI epigenomes. This unique epigenetic feature reveals a previously unknown role of epigenetic order maintenance in specific genomic regions of LLIs, which helps open a new avenue on the epigenetic regulation mechanism in human healthy aging and longevity. |
| 收录类别 | sci |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14264 |
| 专题 | 科研部门_分子人类学（孔庆鹏） |
| 推荐引用方式 GB/T 7714 | Wang, HT,Xiao, FH,Gao, ZL,et al. Methylation entropy landscape of Chinese long-lived individuals reveals lower epigenetic noise related to human healthy aging[J]. AGING CELL,2024,23(7). |
| APA | Wang, HT.,Xiao, FH.,Gao, ZL.,Guo, LY.,Yang, LQ.,...&Kong, QP.(2024).Methylation entropy landscape of Chinese long-lived individuals reveals lower epigenetic noise related to human healthy aging.AGING CELL,23(7). |
| MLA | Wang, HT,et al."Methylation entropy landscape of Chinese long-lived individuals reveals lower epigenetic noise related to human healthy aging".AGING CELL 23.7(2024). |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2024073047.pdf（1735KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论