| A comprehensive diversity analysis on the gut microbiomes of ASD patients: from alpha, beta to gamma diversities |
| Chen, HJ; Li, LW; Yu, FB; Ma, ZS
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| 2024
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| 发表期刊 | FEMS MICROBIOLOGY LETTERS
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| ISSN | 0378-1097
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| 卷号 | 371 |
| 摘要 | Autism spectrum disorder (ASD) is estimated to influence as many as 1% children worldwide, but its etiology is still unclear. It has been suggested that gut microbiomes play an important role in regulating abnormal behaviors associated with ASD. A de facto standard analysis on the microbiome-associated diseases has been diversity analysis, and nevertheless, existing studies on ASD-microbiome relationship have not produced a consensus. Here, we perform a comprehensive analysis of the diversity changes associated with ASD involving alpha-, beta-, and gamma-diversity metrics, based on 8 published data sets consisting of 898 ASD samples and 467 healthy controls (HC) from 16S-rRNA sequencing. Our findings include: (i) In terms of alpha-diversity, in approximately 1/3 of the studies cases, ASD patients exhibited significantly higher alpha-diversity than the HC, which seems to be consistent with the "1/3 conjecture" of diversity-disease relationship (DDR). (ii) In terms of beta-diversity, the AKP (Anna Karenina principle) that predict all healthy microbiomes should be similar, and every diseased microbiome should be dissimilar in its own way seems to be true in approximately 1/2 to 3/4 studies cases. (iii) In terms of gamma-diversity, the DAR (diversity-area relationship) modeling suggests that ASD patients seem to have large diversity-area scaling parameter than the HC, which is consistent with the AKP results. However, the MAD (maximum accrual diversity) and RIP (ratio of individual to population diversity) parameters did not suggest significant differences between ASD patients and HC. Throughout the study, we adopted Hill numbers to measure diversity, which stratified the diversity measures in terms of the rarity-commonness-dominance spectrum. It appears that the differences between ASD patients and HC are more propounding on rare-species side than on dominant-species side. Finally, we discuss the apparent inconsistent diversity-ASD relationships among different case studies and postulate that the relationships are not monotonic. We adopted Hill numbers to measure diversity, which appears that the differences between ASD patients and HC are more propounding on rare-species side than on dominant-species side. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14265
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| 专题 | 科研部门_计算生物与医学生态学（马占山）
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推荐引用方式
GB/T 7714 |
Chen, HJ,Li, LW,Yu, FB,et al. A comprehensive diversity analysis on the gut microbiomes of ASD patients: from alpha, beta to gamma diversities[J]. FEMS MICROBIOLOGY LETTERS,2024,371.
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| APA |
Chen, HJ,Li, LW,Yu, FB,&Ma, ZS.(2024).A comprehensive diversity analysis on the gut microbiomes of ASD patients: from alpha, beta to gamma diversities.FEMS MICROBIOLOGY LETTERS,371.
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| MLA |
Chen, HJ,et al."A comprehensive diversity analysis on the gut microbiomes of ASD patients: from alpha, beta to gamma diversities".FEMS MICROBIOLOGY LETTERS 371(2024).
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