Experimental evidence for cancer resistance in a bat species

	Experimental evidence for cancer resistance in a bat species
	Hua, R; Ma, YS; Yang, L; Hao, JJ; Hua, QY; Shi, LY; Yao, XQ; Zhi, HY; Liu, Z
	2024
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	15 期号:1
摘要	Mammals exhibit different rates of cancer, with long-lived species generally showing greater resistance. Although bats have been suggested to be resistant to cancer due to their longevity, this has yet to be systematically examined. Here, we investigate cancer resistance across seven bat species by activating oncogenic genes in their primary cells. Both in vitro and in vivo experiments suggest that Myotis pilosus (MPI) is particularly resistant to cancer. The transcriptomic and functional analyses reveal that the downregulation of three genes (HIF1A, COPS5, and RPS3) largely contributes to cancer resistance in MPI. Further, we identify the loss of a potential enhancer containing the HIF1A binding site upstream of COPS5 in MPI, resulting in the downregulation of COPS5. These findings not only provide direct experimental evidence for cancer resistance in a bat species but also offer insights into the natural mechanisms of cancer resistance in mammals. Bats have been suggested to be resistant to cancer due to mechanisms related to their evolved longevity, but the associated molecular drivers are still understudied. Here, the authors examine cancer resistance mechanisms across seven bat species using in vitro and in vivo models, and identify HIF1A, COPS5, and RPS3 as related genes.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14278
专题	科研部门_进化发育生物学（刘振）
推荐引用方式 GB/T 7714	Hua, R,Ma, YS,Yang, L,et al. Experimental evidence for cancer resistance in a bat species[J]. NATURE COMMUNICATIONS,2024,15(1).
APA	Hua, R.,Ma, YS.,Yang, L.,Hao, JJ.,Hua, QY.,...&Liu, Z.(2024).Experimental evidence for cancer resistance in a bat species.NATURE COMMUNICATIONS,15(1).
MLA	Hua, R,et al."Experimental evidence for cancer resistance in a bat species".NATURE COMMUNICATIONS 15.1(2024).

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2024073017.pdf（3419KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文