Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

	Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer
	Lu, YW; Ding, ZL; Mao, R; Zhao, GG; He, YQ; Li, XL; Liu, J
	2024
发表期刊	WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
ISSN	1948-5204
卷号	16 期号:2
摘要	BACKGROUND Aberrant methylation is common during the initiation and progression of colorectal cancer (CRC), and detecting these changes that occur during early adenoma (ADE) formation and CRC progression has clinical value. AIM To identify potential DNA methylation markers specific to ADE and CRC. METHODS Here, we performed SeqCap targeted bisulfite sequencing and RNA-seq analysis of colorectal ADE and CRC samples to profile the epigenomic-transcriptomic landscape. RESULTS Comparing 22 CRC and 25 ADE samples, global methylation was higher in the former, but both showed similar methylation patterns regarding differentially methylated gene positions, chromatin signatures, and repeated elements. High-grade CRC tended to exhibit elevated methylation levels in gene promoter regions compared to those in low-grade CRC. Combined with RNA-seq gene expression data, we identified 14 methylation-regulated differentially expressed genes, of which only AGTR1 and NECAB1 methylation had prognostic significance. CONCLUSION Our results suggest that genome-wide alterations in DNA methylation occur during the early stages of CRC and demonstrate the methylation signatures associated with colorectal ADEs and CRC, suggesting prognostic biomarkers for CRC.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14297
专题	科研部门_遗传多样性基因组学研究组（张国捷）
推荐引用方式 GB/T 7714	Lu, YW,Ding, ZL,Mao, R,et al. Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer[J]. WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY,2024,16(2).
APA	Lu, YW.,Ding, ZL.,Mao, R.,Zhao, GG.,He, YQ.,...&Liu, J.(2024).Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer.WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY,16(2).
MLA	Lu, YW,et al."Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer".WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY 16.2(2024).

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2024073120.pdf（15263KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文