Epigenetic signatures of social status in wild female spotted hyenas (Crocuta crocuta)

	Epigenetic signatures of social status in wild female spotted hyenas (Crocuta crocuta)
	Vullioud, C; Benhaiem, S; Meneghini, D; Szyf, M; Shao, Y; Hofer, H; East, ML; Fickel, J; Weyrich, A
	2024
发表期刊	COMMUNICATIONS BIOLOGY
ISSN	2399-3642
卷号	7 期号:1
摘要	In mammalian societies, dominance hierarchies translate into inequalities in health, reproductive performance and survival. DNA methylation is thought to mediate the effects of social status on gene expression and phenotypic outcomes, yet a study of social status-specific DNA methylation profiles in different age classes in a wild social mammal is missing. We tested for social status signatures in DNA methylation profiles in wild female spotted hyenas (Crocuta crocuta), cubs and adults, using non-invasively collected gut epithelium samples. In spotted hyena clans, female social status influences access to resources, foraging behavior, health, reproductive performance and survival. We identified 149 differentially methylated regions between 42 high- and low-ranking female spotted hyenas (cubs and adults). Differentially methylated genes were associated with energy conversion, immune function, glutamate receptor signalling and ion transport. Our results provide evidence that socio-environmental inequalities are reflected at the molecular level in cubs and adults in a wild social mammal.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14300
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Vullioud, C,Benhaiem, S,Meneghini, D,et al. Epigenetic signatures of social status in wild female spotted hyenas (Crocuta crocuta)[J]. COMMUNICATIONS BIOLOGY,2024,7(1).
APA	Vullioud, C.,Benhaiem, S.,Meneghini, D.,Szyf, M.,Shao, Y.,...&Weyrich, A.(2024).Epigenetic signatures of social status in wild female spotted hyenas (Crocuta crocuta).COMMUNICATIONS BIOLOGY,7(1).
MLA	Vullioud, C,et al."Epigenetic signatures of social status in wild female spotted hyenas (Crocuta crocuta)".COMMUNICATIONS BIOLOGY 7.1(2024).

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