| Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development |
| Yue, T; Guo, YB; Qi, XB ; Zheng, WS; Zhang, H; Wang, B; Liu, K; Zhou, B; Zeng, XR; He, YX; Su, B
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| 2024
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| 发表期刊 | ELIFE
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| ISSN | 2050-084X
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| 卷号 | 12 |
| 摘要 | Compared with lowlander migrants, native Tibetans have a higher reproductive success at high altitude though the underlying mechanism remains unclear. Here, we compared the transcriptome and histology of full-term placentas between native Tibetans and Han migrants. We found that the placental trophoblast shows the largest expression divergence between Tibetans and Han, and Tibetans show decreased immune response and endoplasmic reticulum stress. Remarkably, we detected a sex-biased expression divergence, where the male-infant placentas show a greater between-population difference than the female-infant placentas. The umbilical cord plays a key role in the sex-biased expression divergence, which is associated with the higher birth weight of the male newborns of Tibetans. We also identified adaptive histological changes in the male-infant placentas of Tibetans, including larger umbilical artery wall and umbilical artery intima and media, and fewer syncytial knots. These findings provide valuable insights into the sex-biased adaptation of human populations, with significant implications for medical and genetic studies of human reproduction. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14303
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| 专题 | 科研部门_比较基因组学（宿兵）
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推荐引用方式
GB/T 7714 |
Yue, T,Guo, YB,Qi, XB,et al. Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development[J]. ELIFE,2024,12.
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| APA |
Yue, T.,Guo, YB.,Qi, XB.,Zheng, WS.,Zhang, H.,...&Su, B.(2024).Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development.ELIFE,12.
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| MLA |
Yue, T,et al."Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development".ELIFE 12(2024).
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