| Multi-Omics Characteristics of Ferroptosis Associated with Colon Adenocarcinoma Typing and Survival | |
| Chen, XQ; Lian, K; Chen, ZW; Zhang, X; Li, T; Wu, T; Shen, T; Cai, XY; Cheng, XS; Xiao, FH; Li, YF | |
| 2024 | |
| 发表期刊 | FRONTIERS IN BIOSCIENCE-LANDMARK
 |
| ISSN | 2768-6701 |
| 卷号 | 29期号:1 |
| 摘要 | Background: Ferroptosis, an iron-dependent form of cell death, plays a crucial role in the progression of various cancers, including colon adenocarcinoma (COAD). However, the multi-omics signatures relevant to ferroptosis regulation in COAD diagnosis remain to be elucidated. Methods: The transcriptomic, miRNAomic, and methylomic profiles of COAD patients were acquired from the Cancer Genome Atlas (TCGA). Ferroptosis activity in these patients was determined, represented by a ferroptosis score (FS), using single-sample gene set enrichment analysis (ssGSEA) based on the expression of ferroptosis-related genes. Results: Results showed that the COAD patients with high-FS displayed favorable survival outcomes and heightened drug sensitivity. They also exhibited an up-regulation of genes involved in immune-related pathways (e.g., tumor necrosis factor signaling pathway), suggesting a correlation between immunity and ferroptosis in COAD progression. Furthermore, three survival prediction models were established based on 10 CpGs, 12 long non-coding RNAs (lncRNAs), and 14 microRNAs (miRNAs), respectively. These models demonstrated high accuracy in predicting COAD survival, achieving areas under the curve (AUC) >0.7. The variables used in the three models also showed strong correlations at different omics levels and were effective at discriminating between high-FS and low-FS COAD patients (AUC >0.7). Conclusions: This study identified different DNA methylation (DNAm), lncRNA, and miRNA characteristics between COAD patients with high and low ferroptosis activity. Furthermore, ferroptosis-related multi-omics signatures were established for COAD prognosis and classification. These insights present new opportunities for improving the efficacy of COAD therapy. |
| 收录类别 | sci |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14305 |
| 专题 | 科研部门_分子人类学（孔庆鹏） |
| 推荐引用方式 GB/T 7714 | Chen, XQ,Lian, K,Chen, ZW,et al. Multi-Omics Characteristics of Ferroptosis Associated with Colon Adenocarcinoma Typing and Survival[J]. FRONTIERS IN BIOSCIENCE-LANDMARK,2024,29(1). |
| APA | Chen, XQ.,Lian, K.,Chen, ZW.,Zhang, X.,Li, T.,...&Li, YF.(2024).Multi-Omics Characteristics of Ferroptosis Associated with Colon Adenocarcinoma Typing and Survival.FRONTIERS IN BIOSCIENCE-LANDMARK,29(1). |
| MLA | Chen, XQ,et al."Multi-Omics Characteristics of Ferroptosis Associated with Colon Adenocarcinoma Typing and Survival".FRONTIERS IN BIOSCIENCE-LANDMARK 29.1(2024). |
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| 2024073021.pdf（7099KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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