Shared genetic architecture and causal relationship between sleep behaviors and lifespan

	Shared genetic architecture and causal relationship between sleep behaviors and lifespan
	Wu, Y; Zhang, CY; Liu, XL; Wang, L; Li, M; Li, Y; Xiao, X
	2024
发表期刊	TRANSLATIONAL PSYCHIATRY
ISSN	2158-3188
卷号	14 期号:1
摘要	Poor sleep health is associated with a wide array of increased risk for cardiovascular, metabolic and mental health problems as well as all-cause mortality in observational studies, suggesting potential links between sleep health and lifespan. However, it has yet to be determined whether sleep health is genetically or/and causally associated with lifespan. In this study, we firstly studied the genome-wide genetic association between four sleep behaviors (short sleep duration, long sleep duration, insomnia, and sleep chronotype) and lifespan using GWAS summary statistics, and both sleep duration time and insomnia were negatively correlated with lifespan. Then, two-sample Mendelian randomization (MR) and multivariable MR analyses were applied to explore the causal effects between sleep behaviors and lifespan. We found that genetically predicted short sleep duration was causally and negatively associated with lifespan in univariable and multivariable MR analyses, and this effect was partially mediated by coronary artery disease (CAD), type 2 diabetes (T2D) and depression. In contrast, we found that insomnia had no causal effects on lifespan. Our results further confirmed the negative effects of short sleep duration on lifespan and suggested that extension of sleep may benefit the physical health of individuals with sleep loss. Further attention should be given to such public health issues.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14341
专题	科研部门_环境与精神健康（肖潇）
推荐引用方式 GB/T 7714	Wu, Y,Zhang, CY,Liu, XL,et al. Shared genetic architecture and causal relationship between sleep behaviors and lifespan[J]. TRANSLATIONAL PSYCHIATRY,2024,14(1).
APA	Wu, Y.,Zhang, CY.,Liu, XL.,Wang, L.,Li, M.,...&Xiao, X.(2024).Shared genetic architecture and causal relationship between sleep behaviors and lifespan.TRANSLATIONAL PSYCHIATRY,14(1).
MLA	Wu, Y,et al."Shared genetic architecture and causal relationship between sleep behaviors and lifespan".TRANSLATIONAL PSYCHIATRY 14.1(2024).

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2024073033.pdf（1256KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文