Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice

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	Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice
	Hernandez-Benitez, R; Wang, C; Shi, L; Ouchi, Y; Zhong, CQ; Hishida, T; Liao, HK; Magill, EA; Memczak, S; Soligalla, RD; Fresia, C; Hatanaka, F; Lamas, V; Guillen, I; Sahu, S; Yamamoto, M; Shao, YJ; Aguirre-Vazquez, A; Delicado, EN; Guillen, P; Esteban, CR; Qu, J; Reddy, P; Horvath, S; Liu, GH; Magistretti, P; Belmonte, JCI
	2024
发表期刊	CELL REPORTS MEDICINE
ISSN	2666-3791
卷号	5 期号:3
摘要	Tissue regeneration following an injury requires dynamic cell -state transitions that allow for establishing the cell identities required for the restoration of tissue homeostasis and function. Here, we present a biochemical intervention that induces an intermediate cell state mirroring a transition identified during normal differentiation of myoblasts and other multipotent and pluripotent cells to mature cells. When applied in somatic differentiated cells, the intervention, composed of one -carbon metabolites, reduces some dedifferentiation markers without losing the lineage identity, thus inducing limited reprogramming into a more flexible cell state. Moreover, the intervention enabled accelerated repair after muscle injury in young and aged mice. Overall, our study uncovers a conserved biochemical transitional phase that enhances cellular plasticity in vivo and hints at potential and scalable biochemical interventions of use in regenerative medicine and rejuvenation interventions that may be more tractable than genetic ones.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14365
专题	科研部门_神经基因组学（石磊）
推荐引用方式 GB/T 7714	Hernandez-Benitez, R,Wang, C,Shi, L,et al. Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice[J]. CELL REPORTS MEDICINE,2024,5(3).
APA	Hernandez-Benitez, R.,Wang, C.,Shi, L.,Ouchi, Y.,Zhong, CQ.,...&Belmonte, JCI.(2024).Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice.CELL REPORTS MEDICINE,5(3).
MLA	Hernandez-Benitez, R,et al."Intervention with metabolites emulating endogenous cell transitions accelerates muscle regeneration in young and aged mice".CELL REPORTS MEDICINE 5.3(2024).

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