Multiple Origins of Bioluminescence in Beetles and Evolution of Luciferase Function

KIZ OpenIR

	Multiple Origins of Bioluminescence in Beetles and Evolution of Luciferase Function
	He, JW; Li, J; Zhang, R; Dong, ZW; Liu, GC; Chang, Z; Bi, WX; Ruan, YY; Yang, YX; Liu, HY; Qiu, L; Zhao, RP; Wan, WT; Li, ZH; Chen, L; Li, YN; Li, XY
	2024
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	41 期号:1
摘要	Bioluminescence in beetles has long fascinated biologists, with diverse applications in biotechnology. To date, however, our understanding of its evolutionary origin and functional variation mechanisms remains poor. To address these questions, we obtained high-quality reference genomes of luminous and nonluminous beetles in 6 Elateroidea families. We then reconstructed a robust phylogenetic relationship for all luminous families and related nonluminous families. Comparative genomic analyses and biochemical functional experiments suggested that gene evolution within Elateroidea played a crucial role in the origin of bioluminescence, with multiple parallel origins observed in the luminous beetle families. While most luciferase-like proteins exhibited a conserved nonluminous amino acid pattern (TLA346 to 348) in the luciferin-binding sites, luciferases in the different luminous beetle families showed divergent luminous patterns at these sites (TSA/CCA/CSA/LVA). Comparisons of the structural and enzymatic properties of ancestral, extant, and site-directed mutant luciferases further reinforced the important role of these sites in the trade-off between acyl-CoA synthetase and luciferase activities. Furthermore, the evolution of bioluminescent color demonstrated a tendency toward hypsochromic shifts and variations among the luminous families. Taken together, our results revealed multiple parallel origins of bioluminescence and functional divergence within the beetle bioluminescent system.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14377
专题	昆明动物研究所
推荐引用方式 GB/T 7714	He, JW,Li, J,Zhang, R,et al. Multiple Origins of Bioluminescence in Beetles and Evolution of Luciferase Function[J]. MOLECULAR BIOLOGY AND EVOLUTION,2024,41(1).
APA	He, JW.,Li, J.,Zhang, R.,Dong, ZW.,Liu, GC.,...&Li, XY.(2024).Multiple Origins of Bioluminescence in Beetles and Evolution of Luciferase Function.MOLECULAR BIOLOGY AND EVOLUTION,41(1).
MLA	He, JW,et al."Multiple Origins of Bioluminescence in Beetles and Evolution of Luciferase Function".MOLECULAR BIOLOGY AND EVOLUTION 41.1(2024).

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