Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences

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	Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences
	Yu, DQ; Ren, YD; Uesaka, M; Beavan, AJS; Muffato, M; Shen, JY; Li, YX; Sato, I; Wan, WT; Clark, JW; Keating, JN; Carlisle, EM; Dearden, RP; Giles, S; Randle, E; Sansom, RS; Feuda, R; Fleming, JF; Sugahara, F; Cummins, C; Patricio, M; Akanni, W; D'Aniello, S; Bertolucci, C; Irie, N; Alev, C; Sheng, GJ; de Mendoza, A; Maeso, I; Irimia, M; Fromm, B; Peterson, KJ; Das, S; Hirano, M; Rast, JP; Cooper, MD; Paps, J; Pisani, D; Kuratani, S; Martin, FJ; Wang, W; Donoghue, PCJ; Zhang, YE; Pascual-Anaya, J
	2024
发表期刊	NATURE ECOLOGY & EVOLUTION
ISSN	2397-334X
卷号	8 期号:3
摘要	Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hypothesis suggests that two WGD events (1R and 2R) occurred during early vertebrate evolution. However, the timing of the 2R event relative to the divergence of gnathostomes (jawed vertebrates) and cyclostomes (jawless hagfishes and lampreys) is unresolved and whether these WGD events underlie vertebrate phenotypic diversification remains elusive. Here we present the genome of the inshore hagfish, Eptatretus burgeri. Through comparative analysis with lamprey and gnathostome genomes, we reconstruct the early events in cyclostome genome evolution, leveraging insights into the ancestral vertebrate genome. Genome-wide synteny and phylogenetic analyses support a scenario in which 1R occurred in the vertebrate stem-lineage during the early Cambrian, and 2R occurred in the gnathostome stem-lineage, maximally in the late Cambrian-earliest Ordovician, after its divergence from cyclostomes. We find that the genome of stem-cyclostomes experienced an additional independent genome triplication. Functional genomic and morphospace analyses demonstrate that WGD events generally contribute to developmental evolution with similar changes in the regulatory genome of both vertebrate groups. However, appreciable morphological diversification occurred only in the gnathostome but not in the cyclostome lineage, calling into question the general expectation that WGDs lead to leaps of bodyplan complexity. Analysis of a newly sequenced genome of the inshore hagfish, Eptatretus burgeri, together with genomes of lampreys and jawed vertebrates, provides insights into whole-genome duplication events and their implications for vertebrate genome evolution.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14379
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Yu, DQ,Ren, YD,Uesaka, M,et al. Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences[J]. NATURE ECOLOGY & EVOLUTION,2024,8(3).
APA	Yu, DQ.,Ren, YD.,Uesaka, M.,Beavan, AJS.,Muffato, M.,...&Pascual-Anaya, J.(2024).Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences.NATURE ECOLOGY & EVOLUTION,8(3).
MLA	Yu, DQ,et al."Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences".NATURE ECOLOGY & EVOLUTION 8.3(2024).

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2024080122.pdf（16291KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文