FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke

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	FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke
	Li, B; Xi, W; Bai, Y; Liu, X; Zhang, Y; Li, L; Bian, L; Liu, CC; Tang, Y; Shen, L; Yang, L; Gu, XC; Xie, J; Zhou, ZQ; Wang, Y; Yu, XY; Wang, JH; Chao, J; Han, B; Yao, HH
	2023
发表期刊	NATURE COMMUNICATIONS
卷号	14 期号:1
摘要	The mechanisms behind how vascular repair is regulated after ischemic stroke are yet to be elucidated. Here, the authors describe that a circular RNA interacts with FTO to promote vascular repair following stroke in mice and primates via mediating m6 A modification. Vascular repair is considered a key restorative measure to improve long-term outcomes after ischemic stroke. N-6-methyladenosine (m(6)A), the most prevalent internal modification in eukaryotic mRNAs, functionally mediates vascular repair. However, whether circular RNA SCMH1 (circSCMH1) promotes vascular repair by m(6)A methylation after stroke remains to be elucidated. Here, we identify the role of circSCMH1 in promoting vascular repair in peri-infarct cortex of male mice and male monkeys after photothrombotic (PT) stroke, and attenuating the ischemia-induced m(6)A methylation in peri-infarct cortex of male mice after PT stroke. Mechanically, circSCMH1 increased the translocation of ubiquitination-modified fat mass and obesity-associated protein (FTO) into nucleus of endothelial cells (ECs), leading to m(6)A demethylation of phospholipid phosphatase 3 (Plpp3) mRNA and subsequently the increase of Plpp3 expression in ECs. Our data demonstrate that circSCMH1 enhances vascular repair via FTO-regulated m(6)A methylation after stroke, providing insights into the mechanism of circSCMH1 in promoting stroke recovery.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14380
专题	管理、支撑部门_灵长类设施
推荐引用方式 GB/T 7714	Li, B,Xi, W,Bai, Y,et al. FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke[J]. NATURE COMMUNICATIONS,2023,14(1).
APA	Li, B.,Xi, W.,Bai, Y.,Liu, X.,Zhang, Y.,...&Yao, HH.(2023).FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.NATURE COMMUNICATIONS,14(1).
MLA	Li, B,et al."FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke".NATURE COMMUNICATIONS 14.1(2023).

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