A comparison of behavioral paradigms assessing spatial memory in tree shrews

	A comparison of behavioral paradigms assessing spatial memory in tree shrews
	Li, CJ; Hui, YQ; Zhang, R; Zhou, HY; Cai, X; Lu, L
	2023
发表期刊	CEREBRAL CORTEX
ISSN	1047-3211
卷号	33 期号:19 页码:10303-10321
摘要	Impairments in spatial navigation in humans can be preclinical signs of Alzheimer's disease. Therefore, cognitive tests that monitor deficits in spatial memory play a crucial role in evaluating animal models with early stage Alzheimer's disease. While Chinese tree shrews (Tupaia belangeri) possess many features suitable for Alzheimer's disease modeling, behavioral tests for assessing spatial cognition in this species are lacking. Here, we established reward -based paradigms using the radial -arm maze and cheeseboard maze for tree shrews, and tested spatial memory in a group of 12 adult males in both tasks, along with a control water maze test, before and after bilateral lesions to the hippocampus, the brain region essential for spatial navigation. Tree shrews memorized target positions during training, and task performance improved gradually until reaching a plateau in all 3 mazes. However, spatial learning was compromised post -lesion in the 2 newly developed tasks, whereas memory retrieval was impaired in the water maze task. These results indicate that the cheeseboard task effectively detects impairments in spatial memory and holds potential for monitoring progressive cognitive decline in aged or genetically modified tree shrews that develop Alzheimer's disease -like symptoms. This study may facilitate the utilization of tree shrew models in Alzheimer's disease research.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14410
专题	科研部门_空间认识与神冠疾病（卢立）
推荐引用方式 GB/T 7714	Li, CJ,Hui, YQ,Zhang, R,et al. A comparison of behavioral paradigms assessing spatial memory in tree shrews[J]. CEREBRAL CORTEX,2023,33(19):10303-10321.
APA	Li, CJ,Hui, YQ,Zhang, R,Zhou, HY,Cai, X,&Lu, L.(2023).A comparison of behavioral paradigms assessing spatial memory in tree shrews.CEREBRAL CORTEX,33(19),10303-10321.
MLA	Li, CJ,et al."A comparison of behavioral paradigms assessing spatial memory in tree shrews".CEREBRAL CORTEX 33.19(2023):10303-10321.

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