The mechanism of action of Ophiocordyceps sinensis mycelia for prevention of acute lung injury based on non-targeted serum metabolomics

	The mechanism of action of Ophiocordyceps sinensis mycelia for prevention of acute lung injury based on non-targeted serum metabolomics
	Zhou, JN; Pi, N; Guo, YQ; He, XY; Wang, JH; Luo, R; Wang, M; Yu, H
	2023
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	18 期号:6
摘要	Ophiocordyceps sinensis is a fungus with medicinal value in treating lung diseases, but no study has reported how to prevent acute lung injury using this fungus. The mice were divided into normal, model, positive control, and O. sinensis groups to observe lung histopathological sections and transmission electron microscopy, along with liquid chromatography-mass spectrometry and hematoxylin and eosin (H & E) staining to closely identify structural differences resulting from destruction between the groups. The results of the H & E staining showed that, compared with the normal group, the model group showed alveolar collapse. Compared with the model group, the infiltration of inflammatory cells in the alveolar cavity of the O. sinensis group was significantly reduced. Mitochondrial plate-like cristae were observed in type II alveolar cells of the normal group, with normal coloration of the mitochondrial matrix. Type II alveolar cells in the model group showed obvious edema. The statuses of type II alveolar cells in the O. sinensis and positive groups were similar to that in the normal group. Twenty-nine biomarkers and 10 related metabolic pathways were identified by serum metabolomics screening. The results showed that O. sinensis mycelia had a significant effect on the prevention of lipopolysaccharide-induced inflammation.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14412
专题	管理、支撑部门_公共技术服务中心
推荐引用方式 GB/T 7714	Zhou, JN,Pi, N,Guo, YQ,et al. The mechanism of action of Ophiocordyceps sinensis mycelia for prevention of acute lung injury based on non-targeted serum metabolomics[J]. PLOS ONE,2023,18(6).
APA	Zhou, JN.,Pi, N.,Guo, YQ.,He, XY.,Wang, JH.,...&Yu, H.(2023).The mechanism of action of Ophiocordyceps sinensis mycelia for prevention of acute lung injury based on non-targeted serum metabolomics.PLOS ONE,18(6).
MLA	Zhou, JN,et al."The mechanism of action of Ophiocordyceps sinensis mycelia for prevention of acute lung injury based on non-targeted serum metabolomics".PLOS ONE 18.6(2023).

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