ESBL- Escherichia coli extracellular vesicles mediate bacterial resistance to fi-lactam and mediate horizontal transfer of bla CTX-M-55

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	ESBL- Escherichia coli extracellular vesicles mediate bacterial resistance to fi-lactam and mediate horizontal transfer of bla CTX-M-55
	Xu, HT; Tan, C; Li, C; Li, JP; Han, Y; Tang, YZ; Lei, CW; Wang, HN
	2024
发表期刊	INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
ISSN	0924-8579
卷号	63 期号:5
摘要	Objectives: Extracellular vesicles (EVs) have become the focus of research as an emerging method of horizontal gene transfer. In recent years, studies on the association between EVs and the spread of bacterial resistance have emerged, but there is a lack of research on the role of EVs secreted by extended-spectrum fi -lactamase (ESBL)-producing Escherichia coli in the spread of fi -lactam resistance. Therefore, the aim of this study was to investigate the role of EVs in the transmission of fi -lactam resistance. Methods: In this study, the role of EVs in the transmission of fi -lactam resistance in E. coli was evaluated by the EVs-mediated bacterial resistance to fi -lactam antibiotics test and the EVs-mediated bla CTX-M-55 transfer experiments using EVs secreted by ESBL- E. coli . Results: The results showed that ESBL-EVs were protective against fi -lactam antibiotic-susceptible bacteria, and this protective effect was dependent on the integrity of the EVs and showed dose- and timedependent effects. At the same time, ESBL-EVs can also mediate the horizontal transmission of bla CTX-M-55 , and EVs-mediated gene transfer is selective, preferring to transfer in more closely related species. Conclusions: In this study, we demonstrated the important role of EVs in the transmission of fi -lactam resistance in chicken ESBL- E. coli , and evaluated the risk of EVs-mediated horizontal gene transfer, which provided a theoretical basis for elucidating the mechanism of EVs-mediated resistance transmission. (c) 2024 Published by Elsevier Ltd.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14425
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Xu, HT,Tan, C,Li, C,et al. ESBL- Escherichia coli extracellular vesicles mediate bacterial resistance to fi-lactam and mediate horizontal transfer of bla CTX-M-55[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,2024,63(5).
APA	Xu, HT.,Tan, C.,Li, C.,Li, JP.,Han, Y.,...&Wang, HN.(2024).ESBL- Escherichia coli extracellular vesicles mediate bacterial resistance to fi-lactam and mediate horizontal transfer of bla CTX-M-55.INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,63(5).
MLA	Xu, HT,et al."ESBL- Escherichia coli extracellular vesicles mediate bacterial resistance to fi-lactam and mediate horizontal transfer of bla CTX-M-55".INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 63.5(2024).

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