Novel A-seco-nortriterpenoids from Ganoderma cochlear inhibiting Tau pathology by activating AMPK-ULK1-mediated autophagy

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	Novel A-seco-nortriterpenoids from Ganoderma cochlear inhibiting Tau pathology by activating AMPK-ULK1-mediated autophagy
	Luo, RC; Luo, Y; Fang, DS; Yao, YG; Qiu, MH; Peng, XR
	2024
发表期刊	ORGANIC CHEMISTRY FRONTIERS
ISSN	2052-4129
卷号	11 期号:6 页码:1765-1774
摘要	Ten structurally diverse Ganoderma triterpenoids, including one unprecedented highly degraded A-seco-nortriterpenoid, ganolearin A (1) with a 6/6/5-tricyclo structure containing a unique benzene ring, three new rearranged nortriterpenoids, ganolearin B (2) and ganolearin C (3) with a rare 3/5/6/5-fused skeleton, and ganolearin D (4) featuring a 3 -> 10 gamma-lactone ring and a five-membered carbon ring, and six analogues, ganolearates E-G and J (5-7, 10), and ganolearic acids H (8) and I (9), were isolated from the fruiting bodies of Ganoderma cochlear. Their structures were elucidated by extensive 1D and 2D NMR spectroscopy, HRESIMS, X-ray crystallography and ECD calculation analysis. A plausible biosynthetic pathway for 1-4 was proposed. Furthermore, compounds 1-4 significantly inhibited Tau pathology by inducing autophagy mediated by the AMPK-ULK1 pathway, suggesting their potential against Alzheimer's disease (AD).
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14433
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Luo, RC,Luo, Y,Fang, DS,et al. Novel A-seco-nortriterpenoids from Ganoderma cochlear inhibiting Tau pathology by activating AMPK-ULK1-mediated autophagy[J]. ORGANIC CHEMISTRY FRONTIERS,2024,11(6):1765-1774.
APA	Luo, RC,Luo, Y,Fang, DS,Yao, YG,Qiu, MH,&Peng, XR.(2024).Novel A-seco-nortriterpenoids from Ganoderma cochlear inhibiting Tau pathology by activating AMPK-ULK1-mediated autophagy.ORGANIC CHEMISTRY FRONTIERS,11(6),1765-1774.
MLA	Luo, RC,et al."Novel A-seco-nortriterpenoids from Ganoderma cochlear inhibiting Tau pathology by activating AMPK-ULK1-mediated autophagy".ORGANIC CHEMISTRY FRONTIERS 11.6(2024):1765-1774.

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