A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children

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	A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children
	Lin, YP; Shi, YJ; Zhang, RY; Xue, X; Rao, ST; Yin, LY; Lui, KFH; Pan, DJ; Maurer, U; Choy, KW; Paracchini, S; Mcbride, C; So, HC
	2024
发表期刊	NPJ SCIENCE OF LEARNING
ISSN	2056-7936
卷号	9 期号:1
摘要	Dyslexia and developmental language disorders are important learning difficulties. However, their genetic basis remains poorly understood, and most genetic studies were performed on Europeans. There is a lack of genome-wide association studies (GWAS) on literacy phenotypes of Chinese as a native language and English as a second language (ESL) in a Chinese population. In this study, we conducted GWAS on 34 reading/language-related phenotypes in Hong Kong Chinese bilingual children (including both twins and singletons; total N = 1046). We performed association tests at the single-variant, gene, and pathway levels. In addition, we tested genetic overlap of these phenotypes with other neuropsychiatric disorders, as well as cognitive performance (CP) and educational attainment (EA) using polygenic risk score (PRS) analysis. Totally 5 independent loci (LD-clumped at r(2) = 0.01; MAF > 0.05) reached genome-wide significance (p < 5e-08; filtered by imputation quality metric Rsq>0.3 and having at least 2 correlated SNPs (r(2) > 0.5) with p < 1e-3). The loci were associated with a range of language/literacy traits such as Chinese vocabulary, character and word reading, and rapid digit naming, as well as English lexical decision. Several SNPs from these loci mapped to genes that were reported to be associated with EA and other neuropsychiatric phenotypes, such as MANEA and PLXNC1. In PRS analysis, EA and CP showed the most consistent and significant polygenic overlap with a variety of language traits, especially English literacy skills. To summarize, this study revealed the genetic basis of Chinese and English abilities in a group of Chinese bilingual children. Further studies are warranted to replicate the findings.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14437
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Lin, YP,Shi, YJ,Zhang, RY,et al. A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children[J]. NPJ SCIENCE OF LEARNING,2024,9(1).
APA	Lin, YP.,Shi, YJ.,Zhang, RY.,Xue, X.,Rao, ST.,...&So, HC.(2024).A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children.NPJ SCIENCE OF LEARNING,9(1).
MLA	Lin, YP,et al."A genome-wide association study of Chinese and English language phenotypes in Hong Kong Chinese children".NPJ SCIENCE OF LEARNING 9.1(2024).

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