A Light-Responsive Neural Circuit Suppresses Feeding

	A Light-Responsive Neural Circuit Suppresses Feeding
	Liu, HL; Qu, N; Gonzalez, NV; Palma, MA; Chen, HM; Xiong, JN; Choubey, A; Li, YX; Li, X; Yu, M; Liu, HS; Tu, LL; Zhang, N; Yin, N; Conde, KM; Wang, MJ; Bean, JC; Han, JY; Scarcelli, NA; Yang, YJ; Saito, K; Cui, HX; Tong, QC; Sun, Z; Wang, CM; Cai, X; Lu, L; He, Y; Xu, Y
	2024
发表期刊	JOURNAL OF NEUROSCIENCE
ISSN	0270-6474
卷号	44 期号:30
摘要	Light plays an essential role in a variety of physiological processes, including vision, mood, and glucose homeostasis. However, the intricate relationship between light and an animal's feeding behavior has remained elusive. Here, we found that light exposure suppresses food intake, whereas darkness amplifies it in male mice. Interestingly, this phenomenon extends its reach to diurnal male Nile grass rats and healthy humans. We further show that lateral habenula (LHb) neurons in mice respond to light exposure, which in turn activates 5-HT neurons in the dorsal Raphe nucleus (DRN). Activation of the LHb_+5-HTDRNcircuit in mice blunts darkness-induced hyperphagia, while inhibition of the circuit prevents light-induced anorexia. Together, we discovered a lightresponsive neural circuit that relays the environmental light signals to regulate feeding behavior in mice.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14451
专题	科研部门_空间认识与神冠疾病（卢立）
推荐引用方式 GB/T 7714	Liu, HL,Qu, N,Gonzalez, NV,et al. A Light-Responsive Neural Circuit Suppresses Feeding[J]. JOURNAL OF NEUROSCIENCE,2024,44(30).
APA	Liu, HL.,Qu, N.,Gonzalez, NV.,Palma, MA.,Chen, HM.,...&Xu, Y.(2024).A Light-Responsive Neural Circuit Suppresses Feeding.JOURNAL OF NEUROSCIENCE,44(30).
MLA	Liu, HL,et al."A Light-Responsive Neural Circuit Suppresses Feeding".JOURNAL OF NEUROSCIENCE 44.30(2024).

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LL2025040201.pdf（4100KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文