Structural connectivity of thalamic subnuclei in major depressive disorder: An ultra-high resolution diffusion MRI study at 7-Tesla

	Structural connectivity of thalamic subnuclei in major depressive disorder: An ultra-high resolution diffusion MRI study at 7-Tesla
	Liu, WJ; Heij, J; Liu, S; Liebrand, L; Caan, M; van der Zwaag, W; Veltman, DJ; Lu, L; Aghajani, M; van Wingen, G
	2024
发表期刊	JOURNAL OF AFFECTIVE DISORDERS
ISSN	0165-0327
卷号	370 页码:412-426
摘要	Background: The thalamus serves as a central relay station within the brain, and thalamic connectional anomalies are increasingly thought to be present in major depressive disorder (MDD). However, the use of conventional MRI scanners and acquisition techniques has prevented a thorough examination of the thalamus and its sub- nuclear connectional profile. We combined ultra-high field diffusion MRI acquired at 7.0 Tesla to map the white matter connectivity of thalamic subnuclei. Methods: Fifty-three MDD patients and 12 healthy controls (HCs) were involved in the final analysis. FreeSurfer was used to segment the thalamic subnuclei, and MRtrix was used to perform the preprocessing and tractography. Fractional anisotropy, axial diffusivity, mean diffusivity, radial diffusivity, and streamline count of thalamic subnuclear tracts were measured as proxies of white matter microstructure. Bayesian multilevel model was used to assess group differences in white matter metrics for each thalamic subnuclear tract and the association between these white matter metrics and clinical features in MDD. Results: Evidence was found for reduced whiter matter metrics of the tracts spanning from all thalamic subnuclei among MDD versus HC participants. Moreover, evidence was found that white matter in various thalamic subnuclear tracts is related to medication status, age of onset and recurrence in MDD. Conclusions: Structural connectivity was generally reduced in thalamic subnuclei in MDD participants. Several clinical characteristics are related to perturbed subnuclear thalamic connectivity with cortical and subcortical circuits that govern sensory processing, emotional function, and goal-directed behavior.
收录类别	SCI ; SSCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14454
专题	科研部门_生物统计与影像遗传（刘书）
推荐引用方式 GB/T 7714	Liu, WJ,Heij, J,Liu, S,et al. Structural connectivity of thalamic subnuclei in major depressive disorder: An ultra-high resolution diffusion MRI study at 7-Tesla[J]. JOURNAL OF AFFECTIVE DISORDERS,2024,370:412-426.
APA	Liu, WJ.,Heij, J.,Liu, S.,Liebrand, L.,Caan, M.,...&van Wingen, G.(2024).Structural connectivity of thalamic subnuclei in major depressive disorder: An ultra-high resolution diffusion MRI study at 7-Tesla.JOURNAL OF AFFECTIVE DISORDERS,370,412-426.
MLA	Liu, WJ,et al."Structural connectivity of thalamic subnuclei in major depressive disorder: An ultra-high resolution diffusion MRI study at 7-Tesla".JOURNAL OF AFFECTIVE DISORDERS 370(2024):412-426.

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