Dog10K: an integrated Dog10K database summarizing canine multi-omics

	Dog10K: an integrated Dog10K database summarizing canine multi-omics
	Zhou, T; Pu, SY; Zhang, SJ; Zhou, QJ; Zeng, M; Lu, JS; Lu, XM; Wang, YN; Wang, GD
	2024
发表期刊	NUCLEIC ACIDS RESEARCH
ISSN	0305-1048
摘要	The diversity observed in canine breed phenotypes, together with their risk for heritabily disorders of relevance to dogs and humans, makes the species an ideal subject for studies aimed at understanding the genetic basis of complex traits and human biomedical models. Dog10K is an ongoing international collaboration that aims to uncover the genetic basis of phenotypic diversity, disease, behavior, and domestication history of dogs. To best present and make the extensive data accessible and user friendly, we have established the Dog10K (http://dog10k.kiz.ac.cn/) database, a comprehensive-omics resource summarizing multiple types of data. This database integrates single nucleotide variants (SNVs) from 1987 canine genomes, de-novo mutations (DNMs) from 43 dog breeds with >40x sequence, RNA-seq data of 105057 single nuclei from hippocampus, 74067 single cells from leukocytes and 30 blood samples from published canid studies. We provide clear visualization, statistics, browse, searching, and downloading functions for all data. We have integrated three analysis tools, Selscan, LiftOver and AgeConversion, to aid researchers in custom exploration of the comprehensive-omics data. The Dog10K database will serve as a foundational platform for analyzing, presenting and utilizing canine multi-omics data.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14476
专题	科研部门_行为遗传与进化（王国栋）
推荐引用方式 GB/T 7714	Zhou, T,Pu, SY,Zhang, SJ,et al. Dog10K: an integrated Dog10K database summarizing canine multi-omics[J]. NUCLEIC ACIDS RESEARCH,2024.
APA	Zhou, T.,Pu, SY.,Zhang, SJ.,Zhou, QJ.,Zeng, M.,...&Wang, GD.(2024).Dog10K: an integrated Dog10K database summarizing canine multi-omics.NUCLEIC ACIDS RESEARCH.
MLA	Zhou, T,et al."Dog10K: an integrated Dog10K database summarizing canine multi-omics".NUCLEIC ACIDS RESEARCH (2024).

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WGD2025040203.pdf（1320KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文