Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models

	Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models
	Zheng, HY; Song, TZ; Zheng, YT
	2024
发表期刊	ZOOLOGICAL RESEARCH
ISSN	2095-8137
卷号	45 期号:4 页码:747-766
摘要	The distribution of the immune system throughout the body complicates in vitro assessments of coronavirus disease 2019 (COVID-19) immunobiology, often resulting in a lack of reproducibility when extrapolated to the whole organism. Consequently, developing animal models is imperative for a comprehensive understanding of the pathology and immunology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This review summarizes current progress related to COVID-19 animal models, including non-human primates (NHPs), mice, and hamsters, with a focus on their roles in exploring the mechanisms of immunopathology, immune protection, and long-term effects of SARS-CoV-2 infection, as well as their application in immunoprevention and immunotherapy of SARS-CoV-2 infection. Differences among these animal models and their specific applications are also highlighted, COVID-19. To effectively address the challenges posed by diseases.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14483
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Zheng, HY,Song, TZ,Zheng, YT. Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models[J]. ZOOLOGICAL RESEARCH,2024,45(4):747-766.
APA	Zheng, HY,Song, TZ,&Zheng, YT.(2024).Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models.ZOOLOGICAL RESEARCH,45(4),747-766.
MLA	Zheng, HY,et al."Immunobiology of COVID-19: Mechanistic and therapeutic insights from animal models".ZOOLOGICAL RESEARCH 45.4(2024):747-766.

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ZYT2025040717.pdf（3410KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文