| Novel A-seco-nortriterpenoids from Ganoderma cochlear inhibiting Tau pathology by activating AMPK-ULK1-mediated autophagy |
| Luo, RC; Luo, Y; Fang, DS; Yao, YG ; Qiu, MH; Peng, XR
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| 2024
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| 发表期刊 | ORGANIC CHEMISTRY FRONTIERS
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| ISSN | 2052-4129
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| 卷号 | 11期号:6页码:1765-1774 |
| 摘要 | Ten structurally diverse Ganoderma triterpenoids, including one unprecedented highly degraded A-seco-nortriterpenoid, ganolearin A (1) with a 6/6/5-tricyclo structure containing a unique benzene ring, three new rearranged nortriterpenoids, ganolearin B (2) and ganolearin C (3) with a rare 3/5/6/5-fused skeleton, and ganolearin D (4) featuring a 3 -> 10 gamma-lactone ring and a five-membered carbon ring, and six analogues, ganolearates E-G and J (5-7, 10), and ganolearic acids H (8) and I (9), were isolated from the fruiting bodies of Ganoderma cochlear. Their structures were elucidated by extensive 1D and 2D NMR spectroscopy, HRESIMS, X-ray crystallography and ECD calculation analysis. A plausible biosynthetic pathway for 1-4 was proposed. Furthermore, compounds 1-4 significantly inhibited Tau pathology by inducing autophagy mediated by the AMPK-ULK1 pathway, suggesting their potential against Alzheimer's disease (AD). |
| 收录类别 | SCI
; IC
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14499
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| 专题 | 科研部门_疾病机理遗传学和进化医学学科组（姚永刚）
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推荐引用方式
GB/T 7714 |
Luo, RC,Luo, Y,Fang, DS,et al. Novel A-seco-nortriterpenoids from Ganoderma cochlear inhibiting Tau pathology by activating AMPK-ULK1-mediated autophagy[J]. ORGANIC CHEMISTRY FRONTIERS,2024,11(6):1765-1774.
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| APA |
Luo, RC,Luo, Y,Fang, DS,Yao, YG,Qiu, MH,&Peng, XR.(2024).Novel A-seco-nortriterpenoids from Ganoderma cochlear inhibiting Tau pathology by activating AMPK-ULK1-mediated autophagy.ORGANIC CHEMISTRY FRONTIERS,11(6),1765-1774.
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| MLA |
Luo, RC,et al."Novel A-seco-nortriterpenoids from Ganoderma cochlear inhibiting Tau pathology by activating AMPK-ULK1-mediated autophagy".ORGANIC CHEMISTRY FRONTIERS 11.6(2024):1765-1774.
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