| Study of tree shrew biology and models: A booming and prosperous field for biomedical research |
| Yao, YG ; Lu, L; Ni, RJ; Bi, R; Chen, CS; Chen, JQ; Fuchs, E; Gorbatyuk, M; Lei, H; Li, HL; Liu, CY; Lv, LB; Tsukiyama-Kohara, K; Kohara, M; Perez-Cruz, C; Rainer, G; Shan, BC; Shen, F; Tang, AZ; Wang, J; Xia, W; Xia, XS; Xu, L; Yu, DD; Zhang, F; Zheng, P; Zheng, YT; Zhou, JM; Zhou, JN
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| 2024
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| 发表期刊 | ZOOLOGICAL RESEARCH
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| ISSN | 2095-8137
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| 卷号 | 45期号:4页码:877-909 |
| 摘要 | The tree shrew ( Tupaia belangeri ) has long been proposed as a suitable alternative to non-human primates (NHPs) in biomedical and laboratory research due to its close evolutionary relationship with primates. In recent years, significant advances have facilitated tree shrew studies, including the determination of the tree shrew genome, genetic manipulation using spermatogonial stem cells, viral vector-mediated gene delivery, and mapping of the tree shrew brain atlas. However, the limited availability of tree shrews globally remains a substantial challenge in the field. Additionally, determining the key questions best answered using tree shrews constitutes another difficulty. Tree shrew models have historically been used to study hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, myopia, and psychosocial stress-induced depression, with more recent studies focusing on developing animal models for infectious and neurodegenerative diseases. Despite these efforts, the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical research. This review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this model. We emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew studies. The use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models, meeting the increasing demands of life science and biomedical research. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14501
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| 专题 | 科研部门_疾病机理遗传学和进化医学学科组（姚永刚）
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推荐引用方式
GB/T 7714 |
Yao, YG,Lu, L,Ni, RJ,et al. Study of tree shrew biology and models: A booming and prosperous field for biomedical research[J]. ZOOLOGICAL RESEARCH,2024,45(4):877-909.
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| APA |
Yao, YG.,Lu, L.,Ni, RJ.,Bi, R.,Chen, CS.,...&Zhou, JN.(2024).Study of tree shrew biology and models: A booming and prosperous field for biomedical research.ZOOLOGICAL RESEARCH,45(4),877-909.
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| MLA |
Yao, YG,et al."Study of tree shrew biology and models: A booming and prosperous field for biomedical research".ZOOLOGICAL RESEARCH 45.4(2024):877-909.
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