Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer's Disease: A Data-Driven Meta-Analysis with N=3,118

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	Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer's Disease: A Data-Driven Meta-Analysis with N=3,118
	Kang, XP; Wang, DW; Lin, JJ; Yao, HX; Zhao, K; Song, CY; Chen, PD; Qu, YD; Yang, HW; Zhang, ZQ; Zhou, B; Han, T; Liao, ZL; Chen, Y; Lu, J; Yu, CS; Wang, P; Zhang, XQ; Li, M; Zhang, X; Jiang, TZ; Zhou, YY; Liu, B; Han, Y; Liu, Y
	2024
发表期刊	NEUROSCIENCE BULLETIN
ISSN	1673-7067
卷号	40 期号:9 页码:1274-1286
摘要	The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer's disease (AD). We conducted data-driven meta-analyses to combine 3,118 structural magnetic resonance images from three datasets to obtain robust atrophy patterns. Then we introduced a set of radiogenomic analyses to investigate the biological basis of the atrophy patterns in AD. Our results showed that the hippocampus and amygdala exhibit the most severe atrophy, followed by the temporal, frontal, and occipital lobes in mild cognitive impairment (MCI) and AD. The extent of atrophy in MCI was less severe than that in AD. A series of biological processes related to the glutamate signaling pathway, cellular stress response, and synapse structure and function were investigated through gene set enrichment analysis. Our study contributes to understanding the manifestations of atrophy and a deeper understanding of the pathophysiological processes that contribute to atrophy, providing new insight for further clinical research on AD.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14510
专题	科研部门_转化基因组（李明）
推荐引用方式 GB/T 7714	Kang, XP,Wang, DW,Lin, JJ,et al. Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer's Disease: A Data-Driven Meta-Analysis with N=3,118[J]. NEUROSCIENCE BULLETIN,2024,40(9):1274-1286.
APA	Kang, XP.,Wang, DW.,Lin, JJ.,Yao, HX.,Zhao, K.,...&Liu, Y.(2024).Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer's Disease: A Data-Driven Meta-Analysis with N=3,118.NEUROSCIENCE BULLETIN,40(9),1274-1286.
MLA	Kang, XP,et al."Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer's Disease: A Data-Driven Meta-Analysis with N=3,118".NEUROSCIENCE BULLETIN 40.9(2024):1274-1286.

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LM2025040202.pdf（3094KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文