The microbiome's influence on obesity: mechanisms and therapeutic potential

	The microbiome's influence on obesity: mechanisms and therapeutic potential
	Tadese, DA; Mwangi, J; Luo, L; Zhang, H; Huang, XS; Michira, BB; Zhou, SW; Kamau, PM; Lu, QM; Lai, R
	2024
发表期刊	SCIENCE CHINA-LIFE SCIENCES
ISSN	1674-7305
摘要	In 2023, the World Obesity Atlas Federation concluded that more than 50% of the world's population would be overweight or obese within the next 12 years. At the heart of this epidemic lies the gut microbiota, a complex ecosystem that profoundly influences obesity-related metabolic health. Its multifaced role encompasses energy harvesting, inflammation, satiety signaling, gut barrier function, gut-brain communication, and adipose tissue homeostasis. Recognizing the complexities of the cross-talk between host physiology and gut microbiota is crucial for developing cutting-edge, microbiome-targeted therapies to address the global obesity crisis and its alarming health and economic repercussions. This narrative review analyzed the current state of knowledge, illuminating emerging research areas and their implications for leveraging gut microbial manipulations as therapeutic strategies to prevent and treat obesity and related disorders in humans. By elucidating the complex relationship between gut microflora and obesity, we aim to contribute to the growing body of knowledge underpinning this critical field, potentially paving the way for novel interventions to combat the worldwide obesity epidemic.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14528
专题	科研部门_天然药物功能蛋白质学科组（赖仞）
推荐引用方式 GB/T 7714	Tadese, DA,Mwangi, J,Luo, L,et al. The microbiome's influence on obesity: mechanisms and therapeutic potential[J]. SCIENCE CHINA-LIFE SCIENCES,2024.
APA	Tadese, DA.,Mwangi, J.,Luo, L.,Zhang, H.,Huang, XS.,...&Lai, R.(2024).The microbiome's influence on obesity: mechanisms and therapeutic potential.SCIENCE CHINA-LIFE SCIENCES.
MLA	Tadese, DA,et al."The microbiome's influence on obesity: mechanisms and therapeutic potential".SCIENCE CHINA-LIFE SCIENCES (2024).

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LR2025040210.pdf（1148KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文