| Depicting Primate-Like Granular Dorsolateral Prefrontal Cortex in the Chinese Tree Shrew |
| Nie, XP; Xu, XS; Feng, Z; Wang, W; Ma, C; Yang, YX; Li, JN; Zhou, QX; Xu, FQ; Luo, MH; Zhou, JN; Gong, H; Xu, L
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| 2024
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| 发表期刊 | ENEURO
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| 卷号 | 11期号:10 |
| 摘要 | It remains unknown whether the Chinese tree shrew, regarded as the closest sister of primate, has evolved a dorsolateral prefrontal cortex (dlPFC) comparable with primates that is characterized by a fourth layer (L4) enriched with granular cells and reciprocal connections with the mediodorsal nucleus (MD). Here, we reported that following AAV-hSyn-EGFP expression in the MD neurons, the fluorescence micro-optical sectioning tomography revealed their projection trajectories and targeted brain areas, such as the hippocampus, the corpus striatum, and the dlPFC. Cre-dependent transsynaptic viral tracing identified the MD projection terminals that targeted the L4 of the dlPFC, in which the presence of granular cells was confirmed via cytoarchitectural studies by using the Nissl, Golgi, and vGlut2 stainings. Additionally, the L5/6 of the dlPFC projected back to the MD. These results suggest that the tree shrew has evolved a primate-like dlPFC which can serve as an alternative for studying cognition-related functions of the dlPFC. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14534
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| 专题 | 科研部门_学习记忆的分子神经机制（徐林）
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推荐引用方式
GB/T 7714 |
Nie, XP,Xu, XS,Feng, Z,et al. Depicting Primate-Like Granular Dorsolateral Prefrontal Cortex in the Chinese Tree Shrew[J]. ENEURO,2024,11(10).
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| APA |
Nie, XP.,Xu, XS.,Feng, Z.,Wang, W.,Ma, C.,...&Xu, L.(2024).Depicting Primate-Like Granular Dorsolateral Prefrontal Cortex in the Chinese Tree Shrew.ENEURO,11(10).
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| MLA |
Nie, XP,et al."Depicting Primate-Like Granular Dorsolateral Prefrontal Cortex in the Chinese Tree Shrew".ENEURO 11.10(2024).
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