| Lumbar puncture increases Alzheimer's disease biomarker levels in cerebrospinal fluid of rhesus monkeys |
| Xu, JL; Li, H; Hu, YZ; Wu, SH; Wu, LP; Lei, XG; Lv, LB; Lu, Y; Wu, J; Li, JJ; Shi, BY; Li, JL; Turck, CW; Wang, WC; Hu, XT
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| 2024
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| 发表期刊 | ISCIENCE
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| 卷号 | 27期号:4 |
| 摘要 | Cerebrospinal fluid (CSF) samples are commonly collected via lumbar puncture (LP) in both clinical and research settings for measurement of biomarkers of Alzheimer's disease (AD). To determine the effects of LP on CSF AD biomarkers, we collected CSF samples at seven different time points after an LP in rhesus monkeys. We find that amyloid-beta (A b ) and Tau levels increased significantly on day 1, peaked on day 3, and returned to baseline on day 10 after LP. The NFL levels increased significantly on day 5, peaked on day 10, and returned to baseline after day 30. The increased AD biomarker levels were mainly due to CSF outflow and deep intrathecal invasion during LP. Therefore, if LPs are repeated within a short period of time, prior LP can affect A b and Tau levels within 10 days and NFL levels within 30 days, which may lead to clinical misdiagnosis or incorrect scientific conclusions. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14552
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| 专题 | 科研部门_神经系统编码（胡新天）
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推荐引用方式
GB/T 7714 |
Xu, JL,Li, H,Hu, YZ,et al. Lumbar puncture increases Alzheimer's disease biomarker levels in cerebrospinal fluid of rhesus monkeys[J]. ISCIENCE,2024,27(4).
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| APA |
Xu, JL.,Li, H.,Hu, YZ.,Wu, SH.,Wu, LP.,...&Hu, XT.(2024).Lumbar puncture increases Alzheimer's disease biomarker levels in cerebrospinal fluid of rhesus monkeys.ISCIENCE,27(4).
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| MLA |
Xu, JL,et al."Lumbar puncture increases Alzheimer's disease biomarker levels in cerebrospinal fluid of rhesus monkeys".ISCIENCE 27.4(2024).
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