TNFAIP2 promotes HIF1α transcription and breast cancer angiogenesis by activating the Rac1-ERK-AP1 signaling axis

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	TNFAIP2 promotes HIF1α transcription and breast cancer angiogenesis by activating the Rac1-ERK-AP1 signaling axis
	Ren, WL; Liang, HC; Sun, J; Cheng, Z; Liu, WJ; Wu, YY; Shi, YJ; Zhou, ZM; Chen, CS
	2024
发表期刊	CELL DEATH & DISEASE
ISSN	2041-4889
卷号	15 期号:11
摘要	Angiogenesis is well known to play a critical role in breast cancer. We previously reported that TNFAIP2 activates Rac1 to promote triple-negative breast cancer (TNBC) cell proliferation, migration, and chemoresistance. However, the potential contribution of TNFAIP2 to tumor angiogenesis remains unknown. In this study, we demonstrated that TNFAIP2 promotes TNBC angiogenesis by activating the Rac1-ERK-AP1-HIF1 alpha signaling axis. Under hypoxia, TNFAIP2 activates Rac1 and ERK sequentially. Following that, ERK activates the AP-1 (c-Jun/Fra1) transcription factor. By employing chromatin immunoprecipitation and luciferase reporter assays, we showed that AP-1 directly interacts with the HIF1 alpha gene promoter, thereby enhancing its transcription. The combined application of ERK inhibitors, U0126 or trametinib, with the VEGFR inhibitor Apatinib, additively suppresses angiogenesis and tumor growth of HCC1806 in nude mice. These findings provide new therapeutic strategies for TNBC.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14561
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Ren, WL,Liang, HC,Sun, J,et al. TNFAIP2 promotes HIF1α transcription and breast cancer angiogenesis by activating the Rac1-ERK-AP1 signaling axis[J]. CELL DEATH & DISEASE,2024,15(11).
APA	Ren, WL.,Liang, HC.,Sun, J.,Cheng, Z.,Liu, WJ.,...&Chen, CS.(2024).TNFAIP2 promotes HIF1α transcription and breast cancer angiogenesis by activating the Rac1-ERK-AP1 signaling axis.CELL DEATH & DISEASE,15(11).
MLA	Ren, WL,et al."TNFAIP2 promotes HIF1α transcription and breast cancer angiogenesis by activating the Rac1-ERK-AP1 signaling axis".CELL DEATH & DISEASE 15.11(2024).

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