Exploring the Antiproliferative and Antioxidant Effects of Fagonia cretica Thereof: An In Vitro and In Vivo Evaluation

	Exploring the Antiproliferative and Antioxidant Effects of Fagonia cretica Thereof: An In Vitro and In Vivo Evaluation
	Kashif, M; Abbas, A; Nasir, A; Rehman, AU; Rehman, E; Jamal, MA; Kazi, M
	2025
发表期刊	MICROSC RES TECHNIQ
ISSN	1059-910X
摘要	Cancer has appeared as the second leading cause of death worldwide, and breast cancer has become a major health problem due to its high mortality and morbidity. Therefore, there is an urgent need for treatments that have minimal side effects while delivering effective therapeutic outcomes. A wild medicinal plant-derived extract has the potential to cure cancer and decrease side effects. In this study, we characterized the physicochemical properties of Fagonia cretica and evaluated its efficacy and safety as an anticancer drug. Phytochemical analysis revealed the presence of alkaloids, tannins, and saponins, with total phenolic and flavonoid contents of 1.44 +/- 0.01 mg GAE/g and 0.99 +/- 0.02, respectively. Flavonoids and phenols were found to be the primary components in the aqueous extract, and kaempferol-7-o rhamanoside, flavanone, catechin, D-pinitol, arbutin, isorhamnetin, herbacetin-3,8-dimethyl ether, and lupeol were identified through LC-MS analysis. The MTT assay revealed the time- and dose-dependent effects of F. cretica on the viability of cancer cell lines (MCF-7). The scavenging properties also increased in a dose-dependent manner, with the maximum effect occurring at 200 mu g/mL. The in vivo trials revealed that oral treatment with F. cretica at 120 mg/kg in cancer-induced rats significantly improved body weight and regressed the tumor compared with the control (4.09 +/- 0.87 vs. 6.43 +/- 1.21, p < 0.05), as evidenced by histopathology. The liver and kidney functions were normal, and a reduction in the mean corpuscular hemoglobin (MCH) and platelet count was observed after F. cretica treatment. These findings indicate that the aqueous extract of F. cretica possesses anticancer, antioxidant, and cytotoxic properties without adverse effects on liver or kidney functions. The present research provides a theoretical basis for the use of medicinal plants; however, there is still a need to investigate the molecular mechanisms involved.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14584
专题	科研部门_分子进化与基因组多样性（张亚平）
推荐引用方式 GB/T 7714	Kashif, M,Abbas, A,Nasir, A,et al. Exploring the Antiproliferative and Antioxidant Effects of Fagonia cretica Thereof: An In Vitro and In Vivo Evaluation[J]. MICROSC RES TECHNIQ,2025.
APA	Kashif, M.,Abbas, A.,Nasir, A.,Rehman, AU.,Rehman, E.,...&Kazi, M.(2025).Exploring the Antiproliferative and Antioxidant Effects of Fagonia cretica Thereof: An In Vitro and In Vivo Evaluation.MICROSC RES TECHNIQ.
MLA	Kashif, M,et al."Exploring the Antiproliferative and Antioxidant Effects of Fagonia cretica Thereof: An In Vitro and In Vivo Evaluation".MICROSC RES TECHNIQ (2025).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
ZYP2025041009.pdf（508KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文