| The combination of RL-QN15 and OH-CATH30 promotes the repair of acne via the TLR2/NF-κB pathway |
| Huang, YB; Liu, CX; Fu, Z; Li, C; Wu, YT; Jia, QY; Liu, X; Kang, ZJ; Li, YS; Ni, D; Wei, ZQ; Ru, ZQ; Peng, Y; Liu, X; Li, Y; Xiao, ZX; Tang, J ; Wang, Y; Yang, XW
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| 2025
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| 发表期刊 | EUR J PHARMACOL
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| ISSN | 0014-2999
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| 卷号 | 989 |
| 摘要 | Acne is a prevalent and chronic inflammatory skin disease, and its treatment remains a huge clinical challenge. In the present study, we evaluated the therapeutic potential of combining the peptides RL-QN15 and OH-CATH30 for the treatment of acne in mice. Results indicated that the topical application of RL-QN15 and OH-CATH30 significantly inhibited the proliferation of Propionibacterium acnes (P. acnes) and alleviated acne-induced edema. Furthermore, the combined treatment suppressed the overexpression of proinflammatory cytokines induced by P. acnes, including interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha) induced by P. acnes and facilitated collagen deposition, thereby effectively mitigating skin damage associated with acne. Mechanistically, the combination of RL-QN15 and OH-CATH30 inhibited the expression of toll-like receptor 2 (TLR2) and activation nuclear factor kappa-B (NF-kappa B) signaling pathway (phosphorylation of P65 and I kappa B) in both mice and RAW 264.7 cells. These results suggested that this combination may inhibit the excretion of inflammatory factors and facilitate the collagen deposition by TLR2/ NF-kappa B signaling. Overall, our study demonstrates the potent therapeutic effects of the combined application of RL-QN15 and OH-CATH30, highlights the TLR2/NF-kappa B pathway as a key target in acne treatment, and provides a novel strategy for developing innovative acne therapeutics. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14594
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| 专题 | 科研部门_哺乳动物胚胎发育（郑萍）
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推荐引用方式
GB/T 7714 |
Huang, YB,Liu, CX,Fu, Z,et al. The combination of RL-QN15 and OH-CATH30 promotes the repair of acne via the TLR2/NF-κB pathway[J]. EUR J PHARMACOL,2025,989.
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| APA |
Huang, YB.,Liu, CX.,Fu, Z.,Li, C.,Wu, YT.,...&Yang, XW.(2025).The combination of RL-QN15 and OH-CATH30 promotes the repair of acne via the TLR2/NF-κB pathway.EUR J PHARMACOL,989.
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| MLA |
Huang, YB,et al."The combination of RL-QN15 and OH-CATH30 promotes the repair of acne via the TLR2/NF-κB pathway".EUR J PHARMACOL 989(2025).
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