| Remote neurostimulation through an endogenous ion channel using a near-infrared light-activatable nanoagonist |
| Tian, WF; Jia, Q; Lin, JW; Luo, JM; He, DM; Yang, J; Guo, T; Guo, HL; Guo, YS; Zhang, WJ; Chen, FY; Ye, Y; Liu, JJ; Xu, MD; Deng, CJ; Cui, BX; Su, DY; Wang, H; Lu, Y; Xiao, JR; Liu, H ; Yang, J; Hou, ZY; Wang, S
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| 2024
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| 发表期刊 | SCI ADV
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| ISSN | 2375-2548
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| 卷号 | 10期号:32 |
| 摘要 | The development of noninvasive approaches to precisely control neural activity in mammals is highly desirable. Here, we used the ion channel transient receptor potential ankyrin-repeat 1 (TRPA1) as a proof of principle, demonstrating remote near-infrared (NIR) activation of endogenous neuronal channels in mice through an engineered nanoagonist. This achievement enables specific neurostimulation in nongenetically modified mice. Initially, target-based screening identified flavins as photopharmacological agonists, allowing for the photoactivation of TRPA1 in sensory neurons upon ultraviolet A/blue light illumination. Subsequently, upconversion nanoparticles (UCNPs) were customized with an emission spectrum aligned to flavin absorption and conjugated with flavin adenine dinucleotide, creating a nanoagonist capable of NIR activation of TRPA1. Following the intrathecal injection of the nanoagonist, noninvasive NIR stimulation allows precise bidirectional control of nociception in mice through remote activation of spinal TRPA1. This study demonstrates a noninvasive NIR neurostimulation method with the potential for adaptation to various endogenous ion channels and neural processes by combining photochemical toolboxes with customized UCNPs. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14607
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| 专题 | 科研部门_天然药物功能蛋白质学科组（赖仞）
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推荐引用方式
GB/T 7714 |
Tian, WF,Jia, Q,Lin, JW,et al. Remote neurostimulation through an endogenous ion channel using a near-infrared light-activatable nanoagonist[J]. SCI ADV,2024,10(32).
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| APA |
Tian, WF.,Jia, Q.,Lin, JW.,Luo, JM.,He, DM.,...&Wang, S.(2024).Remote neurostimulation through an endogenous ion channel using a near-infrared light-activatable nanoagonist.SCI ADV,10(32).
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| MLA |
Tian, WF,et al."Remote neurostimulation through an endogenous ion channel using a near-infrared light-activatable nanoagonist".SCI ADV 10.32(2024).
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