A Concise Synthesis of (2R,6R)-Hydroxynorketamine

	A Concise Synthesis of (2R,6R)-Hydroxynorketamine
	Li, JF; Zhou, AK; Wang, XT; Zhang, WP; Zhou, QX; Li, N
	2024
发表期刊	J ORG CHEM
ISSN	0022-3263
卷号	89 期号:22 页码:16909-16916
摘要	A concise synthesis of (2R,6R)-hydroxynorketamine was accomplished in eight steps, starting from commercially available materials. This synthesis features a cerium chloride-enhanced Stork-Danheiser reaction, an asymmetric reduction of ketone by the Corey-Bakshi-Shibata reaction, a signature Overman rearrangement, and a facial selective dihydroxylation of an electronically deficient olefin by RuCl3/NaIO4. The overall yield is 7.3% with 94.5% ee.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14610
专题	科研部门_学习记忆的分子神经机制（徐林）
推荐引用方式 GB/T 7714	Li, JF,Zhou, AK,Wang, XT,et al. A Concise Synthesis of (2R,6R)-Hydroxynorketamine[J]. J ORG CHEM,2024,89(22):16909-16916.
APA	Li, JF,Zhou, AK,Wang, XT,Zhang, WP,Zhou, QX,&Li, N.(2024).A Concise Synthesis of (2R,6R)-Hydroxynorketamine.J ORG CHEM,89(22),16909-16916.
MLA	Li, JF,et al."A Concise Synthesis of (2R,6R)-Hydroxynorketamine".J ORG CHEM 89.22(2024):16909-16916.