| Identification of lncRNA-mRNA network linking ferroptosis and immune infiltration to colon adenocarcinoma suppression | |
| Chen, XQ; Zhang, X; Pan, DG; Li, GY; Hu, RX; Wu, T; Shen, T; Cai, XY; Cheng, XS; Qin, JY; Xiao, FH; Li, YF | |
| 2024 | |
| 发表期刊 | HELIYON
 |
| 卷号 | 10期号:13 |
| 摘要 | Background: Colon adenocarcinoma (COAD) is one of the most common malignant tumors. The interplay involving ferroptosis between tumor and immune cells plays a crucial in cancer progression. However, the biological basis of this interplay in COAD development remains elusive. Methods: Transcriptome data of COAD samples were obtained from The Cancer Genome Atlas and National Center for Biotechnology Information databases. Using single-sample gene set enrichment analysis, we calculated the ferroptosis score (FS) and immune cell infiltration levels for each sample, leveraging the expression levels of genes related to ferroptosis and various immune cell types. Samples with FSs greater than the 75th percentile were classified into the high-FS subgroup, while those below the 25th percentile were categorized as the low-FS subgroup. Moreover, tumor tissue samples and adjacent normal tissue samples were collected from twenty colon patients. Using real-time quantitative polymerase chain reaction, we validated the expression of certain genes in these samples. Results: The COAD samples with high FSs experienced favorable survival probability and heightened sensitivity to anticancer drugs, with FSs negatively associated with the pathological stages. Moreover, the up-regulated genes in high-FS subgroup exhibited enrichment in immune- related pathways, suggesting a correlation between immunity and ferroptosis. Importantly, we discovered a key lncRNA-mRNA co-expression network linking tumor cell ferroptosis and immune infiltration (e.g., neutrophil) in the progression and classification of COAD. Further analysis identified several ferroptosis-related lncRNAs (e.g., RP11-399O19.9) ) within this network, indicating their potential roles in COAD progression and deserving in-depth study. Conclusions: Our findings provide novel insights into the underlying biological basis, particularly involving lncRNAs, at gene expression level associated with ferroptosis in COAD and cancer therapy. Nevertheless, further analysis and validation are required to expand the findings. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14616 |
| 专题 | 科研部门_分子人类学（孔庆鹏） |
| 推荐引用方式 GB/T 7714 | Chen, XQ,Zhang, X,Pan, DG,et al. Identification of lncRNA-mRNA network linking ferroptosis and immune infiltration to colon adenocarcinoma suppression[J]. HELIYON,2024,10(13). |
| APA | Chen, XQ.,Zhang, X.,Pan, DG.,Li, GY.,Hu, RX.,...&Li, YF.(2024).Identification of lncRNA-mRNA network linking ferroptosis and immune infiltration to colon adenocarcinoma suppression.HELIYON,10(13). |
| MLA | Chen, XQ,et al."Identification of lncRNA-mRNA network linking ferroptosis and immune infiltration to colon adenocarcinoma suppression".HELIYON 10.13(2024). |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| KQP2025041004.pdf（8938KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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