Juvenile hormone as a key regulator for asymmetric caste differentiation in ants

	Juvenile hormone as a key regulator for asymmetric caste differentiation in ants
	Li, RY; Dai, XQ; Zheng, JX; Larsen, RS; Qi, YM; Zhang, XF; Vizueta, J; Boomsma, JJ; Liu, WW; Zhang, GJ
	2024
发表期刊	P NATL ACAD SCI USA
ISSN	0027-8424
卷号	121 期号:46
摘要	Caste differentiation involves many functional traits that diverge during larval growth and metamorphosis to produce adults irreversibly adapted to reproductive division of labor. Investigating developmental differentiation is important for general biological understanding and has increasingly been explored for social phenotypes that diverge in parallel from similar genotypes. Here, we use Monomorium pharaonis ants to investigate the extent to which canalized worker development can be shifted toward gyne (virgin- queen) phenotypes by juvenile hormone (JH) treatment. We show that excess JH can activate gyne- biased development in workers so that wing- buds, ocelli, antennal and genital imaginal discs, flight muscles, and gyne- like fat bodies and brains emerge after pupation. However, ovary development remained unresponsive to JH treatment, indicating that JH- sensitive germline sequestration happens well before somatic differentiation. Our findings reveal important qualitative restrictions in the extent to which JH treatment can redirect larval development and that these constraints are independent of body size. Our findings corroborate that JH is a key hormone for inducing caste differentiation but show that this process can be asymmetric for higher colony- level germline versus somatic caste differentiation in superorganisms as defined a century ago by Wheeler. We quantified gene expression changes in response to JH treatment throughout development and identified a set of JH- sensitive genes responsible for the emergence of gyne- like somatic traits. Our study suggests that the gonadotropic role of JH in ovary maturation has shifted from the individual level in solitary insects to the colony level in an evolutionary- derived and highly polygynous superorganism like the pharaoh ant.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14624
专题	科研部门_遗传多样性基因组学研究组（张国捷）
推荐引用方式 GB/T 7714	Li, RY,Dai, XQ,Zheng, JX,et al. Juvenile hormone as a key regulator for asymmetric caste differentiation in ants[J]. P NATL ACAD SCI USA,2024,121(46).
APA	Li, RY.,Dai, XQ.,Zheng, JX.,Larsen, RS.,Qi, YM.,...&Zhang, GJ.(2024).Juvenile hormone as a key regulator for asymmetric caste differentiation in ants.P NATL ACAD SCI USA,121(46).
MLA	Li, RY,et al."Juvenile hormone as a key regulator for asymmetric caste differentiation in ants".P NATL ACAD SCI USA 121.46(2024).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
ZGJ2025042103.pdf（3525KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文