An evolutionarily conserved pathway mediated by neuroparsin-A regulates reproductive plasticity in ants

	An evolutionarily conserved pathway mediated by neuroparsin-A regulates reproductive plasticity in ants
	Zhang, XF; Xie, NX; Ding, G; Ning, DD; Dai, W; Xiong, ZJ; Zhong, WJ; Zuo, DS; Zhao, J; Zhang, P; Liu, CY; Li, QY; Ran, H; Liu, WW; Zhang, GJ
	2024
发表期刊	PLOS BIOL
ISSN	1544-9173
卷号	22 期号:8
摘要	Phenotypic plasticity displayed by an animal in response to different environmental conditions is supposedly crucial for its survival and reproduction. The female adults of some ant lineages display phenotypic plasticity related to reproductive role. In pharaoh ant queens, insemination induces substantial physiological/behavioral changes and implicates remarkable gene regulatory network (GRN) shift in the brain. Here, we report a neuropeptide neuroparsin A (NPA) showing a conserved expression pattern associated with reproductive activity across ant species. Knock-down of NPA in unmated queen enhances ovary activity, whereas injection of NPA peptide in fertilized queen suppresses ovary activity. We found that NPA mainly affected the downstream gene JHBP in the ovary, which is positively regulated by NPA and suppression of which induces elevated ovary activity, and shadow which is negatively regulated by NPA. Furthermore, we show that NPA was also employed into the brain-ovary axis in regulating the worker reproductive changes in other distantly related species, such as Harpegnathos venator ants. Some female ants display phenotypic plasticity related to reproduction, such as the transition between gyne and queen castes. This study shows that the neuropeptide neuroparsin A mediates substantial physiological changes in response to insemination across ant species, acting via ovarian endocrine pathways.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14625
专题	科研部门_遗传多样性基因组学研究组（张国捷）
推荐引用方式 GB/T 7714	Zhang, XF,Xie, NX,Ding, G,et al. An evolutionarily conserved pathway mediated by neuroparsin-A regulates reproductive plasticity in ants[J]. PLOS BIOL,2024,22(8).
APA	Zhang, XF.,Xie, NX.,Ding, G.,Ning, DD.,Dai, W.,...&Zhang, GJ.(2024).An evolutionarily conserved pathway mediated by neuroparsin-A regulates reproductive plasticity in ants.PLOS BIOL,22(8).
MLA	Zhang, XF,et al."An evolutionarily conserved pathway mediated by neuroparsin-A regulates reproductive plasticity in ants".PLOS BIOL 22.8(2024).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
ZGJ2025042104.pdf（3310KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文