Novel analgesic peptide derived from Cinobufacini injection suppressing inflammation and pain via ERK1/2/COX-2 pathway

	Novel analgesic peptide derived from Cinobufacini injection suppressing inflammation and pain via ERK1/2/COX-2 pathway
	Guo, L; Zhang, S; Zhang, C; Ren, S; Zhou, ZH; Wang, FY; Wang, YX; Chen, QQ; Wang, YB; Lee, WH; Zhu, K; Qin, D; Gao, YY; Sun, TY
	2024
发表期刊	INT IMMUNOPHARMACOL
ISSN	1567-5769
卷号	141
摘要	Inflammatory pain is a chronic pain caused by peripheral tissue inflammation, seriously impacting the patient's life quality. Cinobufacini injection, as a traditional Chinese medicine injection preparation, shows excellent efficacy in anti-inflammatory and analgesic treatment in patients with advanced tumors. In this study, a novel analgesic peptide CI5 with anti-inflammatory and analgesic bio-functions that naturally presents in Cinobufacini injection and its regulatory mechanism are reported. Our results showed that the administration of CI5 significantly relieved the pain of mice in the acetic acid twisting analgesic model and formalin inflammatory pain model. Furthermore, CI5 effectively reduced the inflammatory cytokines (IL-6, TNF-alpha and IL-1 beta) and inflammatory mediator (PGE2) expressions, and prevented the carrageenan-induced paw edema in mice. Further LCMS/MS results showed the anti-inflammatory and analgesic bio-functions of CI5 depended on its interaction with the Rac-2 protein upstream of ERK1/2 and the inflammatory signaling pathway (ERK1/2/COX-2 axis). In summary, CI5, as a novel natural candidate identified from Cinobufacini injection, showed substantial clinical promise for inflammatory pain treatments.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14671
专题	科研部门_生物毒素与人类疾病（张云）
推荐引用方式 GB/T 7714	Guo, L,Zhang, S,Zhang, C,et al. Novel analgesic peptide derived from Cinobufacini injection suppressing inflammation and pain via ERK1/2/COX-2 pathway[J]. INT IMMUNOPHARMACOL,2024,141.
APA	Guo, L.,Zhang, S.,Zhang, C.,Ren, S.,Zhou, ZH.,...&Sun, TY.(2024).Novel analgesic peptide derived from Cinobufacini injection suppressing inflammation and pain via ERK1/2/COX-2 pathway.INT IMMUNOPHARMACOL,141.
MLA	Guo, L,et al."Novel analgesic peptide derived from Cinobufacini injection suppressing inflammation and pain via ERK1/2/COX-2 pathway".INT IMMUNOPHARMACOL 141(2024).

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