State-specific Regulation of Electrical Stimulation in the Intralaminar Thalamus of Macaque Monkeys: Network and Transcriptional Insights into Arousal

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	State-specific Regulation of Electrical Stimulation in the Intralaminar Thalamus of Macaque Monkeys: Network and Transcriptional Insights into Arousal
	Zhang, Z; Huang, YC; Chen, XY; Li, JH; Yang, Y; Lv, LB; Wang, JH; Wang, MY; Wang, YW; Wang, Z
	2024
发表期刊	ADV SCI
卷号	11 期号:33
摘要	Long-range thalamocortical communication is central to anesthesia-induced loss of consciousness and its reversal. However, isolating the specific neural networks connecting thalamic nuclei with various cortical regions for state-specific anesthesia regulation is challenging, with the biological underpinnings still largely unknown. Here, simultaneous electroencephalogram-fuctional magnetic resonance imaging (EEG-fMRI) and deep brain stimulation are applied to the intralaminar thalamus in macaques under finely-tuned propofol anesthesia. This approach led to the identification of an intralaminar-driven network responsible for rapid arousal during slow-wave oscillations. A network-based RNA-sequencing analysis is conducted of region-, layer-, and cell-specific gene expression data from independent transcriptomic atlases and identifies 2489 genes preferentially expressed within this arousal network, notably enriched in potassium channels and excitatory, parvalbumin-expressing neurons, and oligodendrocytes. Comparison with human RNA-sequencing data highlights conserved molecular and cellular architectures that enable the matching of homologous genes, protein interactions, and cell types across primates, providing novel insight into network-focused transcriptional signatures of arousal.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14686
专题	昆明动物研究所
推荐引用方式 GB/T 7714	Zhang, Z,Huang, YC,Chen, XY,et al. State-specific Regulation of Electrical Stimulation in the Intralaminar Thalamus of Macaque Monkeys: Network and Transcriptional Insights into Arousal[J]. ADV SCI,2024,11(33).
APA	Zhang, Z.,Huang, YC.,Chen, XY.,Li, JH.,Yang, Y.,...&Wang, Z.(2024).State-specific Regulation of Electrical Stimulation in the Intralaminar Thalamus of Macaque Monkeys: Network and Transcriptional Insights into Arousal.ADV SCI,11(33).
MLA	Zhang, Z,et al."State-specific Regulation of Electrical Stimulation in the Intralaminar Thalamus of Macaque Monkeys: Network and Transcriptional Insights into Arousal".ADV SCI 11.33(2024).

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CWT2025042101.pdf（5400KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文